Difference between revisions of "Thyroid gland"

Jump to navigation Jump to search

Thyroid gland (view source)

Revision as of 21:17, 17 January 2011

339 bytes added ,  21:17, 17 January 2011
+lymphoma
(+lymphoma)
Line 2: Line 2:


=Thyroid specimens=
=Thyroid specimens=
They come in 3 common varieties:
==They come in 3 common varieties==
*Hemithyroid.
*Hemithyroid.
**Done to get a definitive diagnosis.
**Done to get a definitive diagnosis.
Line 11: Line 11:
**done to r/o malignancy.
**done to r/o malignancy.


Gross pathology:
==Gross pathology==
*White nodules - think:
*White nodules - think:
**Lymphoid tissue.
**Lymphoid tissue.
Line 35: Line 35:
*Thick capsule.
*Thick capsule.
*Necrosis - rare in the thyroid.
*Necrosis - rare in the thyroid.
==Thyroid IHC - general comments==
*Not really useful.
*Papers with very small sample sizes abound.
===Follicular thyroid carcinoma vs. papillary thyroid carcinoma===
*CD31 more frequently positive in follicular lesions.<ref name=pmid18795075>{{Cite journal  | last1 = Rydlova | first1 = M. | last2 = Ludvikova | first2 = M. | last3 = Stankova | first3 = I. | title = Potential diagnostic markers in nodular lesions of the thyroid gland: an immunohistochemical study. | journal = Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | volume = 152 | issue = 1 | pages = 53-9 | month = Jun | year = 2008 | doi =  | PMID = 18795075 }}</ref>
**CD31 is a marker for microvessel density.
*Galectin-3 thought to be positive in papillary carcinoma.<ref name=pmid18795075/>
*HBME-1 thought to be positive in papillary lesions.<ref name=pmid15529186>{{Cite journal  | last1 = Papotti | first1 = M. | last2 = Rodriguez | first2 = J. | last3 = De Pompa | first3 = R. | last4 = Bartolazzi | first4 = A. | last5 = Rosai | first5 = J. | title = Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential. | journal = Mod Pathol | volume = 18 | issue = 4 | pages = 541-6 | month = Apr | year = 2005 | doi = 10.1038/modpathol.3800321 | PMID = 15529186 }}</ref>


=Parathyroid tissue=
=Parathyroid tissue=
Line 453: Line 463:
*TTF-1 +ve.
*TTF-1 +ve.


==Thyroid IHC - general comments==
==Lymphomas of the thyroid==
*Not really useful.
{{Main|Lymphoma}}
*Papers with very small sample sizes abound.
===General===
*Rare.
===Follicular thyroid carcinoma vs. papillary thyroid carcinoma===
*Increased risk with chronic inflammatory conditions.
*CD31 more frequently positive in follicular lesions.<ref name=pmid18795075>{{Cite journal  | last1 = Rydlova | first1 = M. | last2 = Ludvikova | first2 = M. | last3 = Stankova | first3 = I. | title = Potential diagnostic markers in nodular lesions of the thyroid gland: an immunohistochemical study. | journal = Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | volume = 152 | issue = 1 | pages = 53-9 | month = Jun | year = 2008 | doi = | PMID = 18795075 }}</ref>
*Fit in the the greater category of ''[[MALT lymphoma]]''.
**CD31 is a marker for microvessel density.
 
*Galectin-3 thought to be positive in papillary carcinoma.<ref name=pmid18795075/>
===Microscopic===
*HBME-1 thought to be positive in papillary lesions.<ref name=pmid15529186>{{Cite journal  | last1 = Papotti | first1 = M. | last2 = Rodriguez | first2 = J. | last3 = De Pompa | first3 = R. | last4 = Bartolazzi | first4 = A. | last5 = Rosai | first5 = J. | title = Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential. | journal = Mod Pathol | volume = 18 | issue = 4 | pages = 541-6 | month = Apr | year = 2005 | doi = 10.1038/modpathol.3800321 | PMID = 15529186 }}</ref>
Features:
*Lymphoepithelial lesion - '''key feature'''.
*Plasma cells.
*"Overgrowth" - thyroid parenchyma displaced by lymphocytes.


=See also=
=See also=
Michael
48,830

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/3688"

Navigation menu