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Difference between revisions of "Thyroid gland"
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→Papillary: more on subtypes
(→Microscopic: reword) |
(→Papillary: more on subtypes) |
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There are a bunch of 'em. The most common, by far, is papillary. | There are a bunch of 'em. The most common, by far, is papillary. | ||
==Papillary== | ==Papillary thyroid carcinoma== | ||
=== | *Abbreviated ''PTC''. | ||
===General=== | |||
Medical school memory device P's: | |||
*Palpable nodes. | *Palpable nodes. | ||
*Popular (most common malignant neoplasm of the thyroid). | *Popular (most common malignant neoplasm of the thyroid). | ||
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===Tall cell variant=== | ===Tall cell variant=== | ||
====General==== | |||
*~10% of PTC. | |||
====Microscopic==== | |||
Features:<ref name=pmid19373912>{{cite journal |author=Urano M, Kiriyama Y, Takakuwa Y, Kuroda M |title=Tall cell variant of papillary thyroid carcinoma: Its characteristic features demonstrated by fine-needle aspiration cytology and immunohistochemical study |journal=Diagn. Cytopathol. |volume= |issue= |pages= |year=2009 |month=April |pmid=19373912 |doi=10.1002/dc.21086 |url=}}</ref> | Features:<ref name=pmid19373912>{{cite journal |author=Urano M, Kiriyama Y, Takakuwa Y, Kuroda M |title=Tall cell variant of papillary thyroid carcinoma: Its characteristic features demonstrated by fine-needle aspiration cytology and immunohistochemical study |journal=Diagn. Cytopathol. |volume= |issue= |pages= |year=2009 |month=April |pmid=19373912 |doi=10.1002/dc.21086 |url=}}</ref> | ||
*50% of cells with height 2x the width.<ref>[http://pathologyoutlines.com/thyroid.html#tallcellvariant http://pathologyoutlines.com/thyroid.html#tallcellvariant]</ref><ref name=pmid18925842>{{cite journal |author=Ghossein R, Livolsi VA |title=Papillary thyroid carcinoma tall cell variant |journal=Thyroid |volume=18 |issue=11 |pages=1179–81 |year=2008 |month=November |pmid=18925842 |doi=10.1089/thy.2008.0164 |url=}}</ref> | *50% of cells with height 2x the width.<ref>[http://pathologyoutlines.com/thyroid.html#tallcellvariant http://pathologyoutlines.com/thyroid.html#tallcellvariant]</ref><ref name=pmid18925842>{{cite journal |author=Ghossein R, Livolsi VA |title=Papillary thyroid carcinoma tall cell variant |journal=Thyroid |volume=18 |issue=11 |pages=1179–81 |year=2008 |month=November |pmid=18925842 |doi=10.1089/thy.2008.0164 |url=}}</ref> | ||
**There is some disagreement on these criteria | **There is some disagreement on these criteria;<ref name=pmid18925842/> SR believes height ought to be ~3x width, for 50% of the cells.<ref>SR. 17 January 2011.</ref> | ||
*Eosinophilic cytoplasm. | *Eosinophilic cytoplasm. | ||
*Well-defined cell borders. | *Well-defined cell borders. | ||
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===Columnar cell variant=== | ===Columnar cell variant=== | ||
====General==== | |||
Epidemiology: | Epidemiology: | ||
*Poor prognosis. | *Poor prognosis. | ||
*Very rare. | |||
====Microscopic==== | |||
Features: | Features: | ||
*Elongated nuclei (similar to colorectal adenocarcinoma) - '''key feature'''. | *Elongated nuclei (similar to colorectal adenocarcinoma) - '''key feature'''. | ||
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Image: [http://www3.interscience.wiley.com/cgi-bin/fulltext/75000320/nfig003a?CRETRY=1&SRETRY=0 Tall cell variant Pa ca (wiley.com)]. | Image: [http://www3.interscience.wiley.com/cgi-bin/fulltext/75000320/nfig003a?CRETRY=1&SRETRY=0 Tall cell variant Pa ca (wiley.com)]. | ||
===Follicular variant=== | ===Follicular variant=== | ||
====General==== | |||
May be confused with follicular carcinoma or follicular adenoma. | May be confused with follicular carcinoma or follicular adenoma. | ||
====Microscopic==== | |||
Features: | Features: | ||
*Prominent follicles. | *Prominent follicles. | ||
===Cribriform-morular variant=== | ===Cribriform-morular variant=== | ||
====General==== | |||
*Associated [[familial adenomatous polyposis]] (FAP). | |||
====Microscopic==== | |||
Features: | Features: | ||
*Cribriform pattern. | *Cribriform pattern. | ||