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Difference between revisions of "TFEB-rearranged renal cell carcinoma"
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TFEB-rearranged renal cell carcinoma (view source)
Revision as of 06:10, 5 January 2015
, 06:10, 5 January 2015more
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid18998233>{{Cite journal | last1 = Hora | first1 = M. | last2 = Hes | first2 = O. | last3 = Urge | first3 = T. | last4 = Eret | first4 = V. | last5 = Klecka | first5 = J. | last6 = Michal | first6 = M. | title = A distinctive translocation carcinoma of the kidney ["rosette-like forming," t(6;11), HMB45-positive renal tumor]. | journal = Int Urol Nephrol | volume = 41 | issue = 3 | pages = 553-7 | month = | year = 2009 | doi = 10.1007/s11255-008-9495-8 | PMID = 18998233 }}</ref> | ||
* | *Solid with occasional rosette-like structures. | ||
*Large cells with clear to eosinophilic cytoplasm. | *Two cell populations: | ||
*#Large epithelioid cells with clear to eosinophilic cytoplasm. | |||
*#Small lymphocyte-like cells. | |||
DDx: | |||
*[[Renal cell carcinoma, unclassified]]. | |||
*[[Angiomyolipoma]] (epithelioid). | |||
===Images=== | ===Images=== | ||
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*TFEB +ve (nuclear staining). | *TFEB +ve (nuclear staining). | ||
*HMB-45 +ve<ref name=pmid24877033/> (focal<ref name=pmid12719541/>). | *HMB-45 +ve<ref name=pmid24877033/> (focal<ref name=pmid12719541/>). | ||
*TFE3 -ve. | |||
==Molecular== | ==Molecular== | ||