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Difference between revisions of "Astrocytoma"
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An '''astrocytoma''' is a neoplasm derived from an [[neurohistology|astrocyte]]. Astrocytomas are common. This article deals with, among other things, rare astrocytomas. An overview of CNS tumours is found in the ''[[CNS tumours]]'' article. | An '''astrocytoma''' is a neoplasm derived from an [[neurohistology|astrocyte]]. Astrocytomas are common. This article deals with, among other things, rare astrocytomas. An overview of CNS tumours is found in the ''[[CNS tumours]]'' article. | ||
=Other= | |||
==Pleomorphic xanthroastrocytoma== | |||
*Abbreviated ''PXA''. | |||
===General=== | |||
*Kids & young adults. | |||
*Prognosis usu. good. | |||
===Microscopic=== | |||
Features: | |||
*Large cells with intracytoplasmic lipid accumulation, i.e. foamy cytoplasm - '''key features'''.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm]. Accessed on: 13 January 2011.</ref> | |||
**May not be obvious/one may have to search for this. | |||
*Focal marked nuclear atypia - including hyperchromasia, marked nuclear enlargement, irregular chromatin. | |||
*Multinucleation - common. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Pleo_xantho.jpg PXA (WC/AFIP)]. | |||
*[http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm PXA (ouhsc.edu)]. | |||
*[http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970469-7&figureId=fig1&ddx=true PXA (pathconsultddx.com)]. | |||
===IHC=== | |||
Features:<Ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970469-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970469-7]. Accessed on: 13 January 2011.</ref> | |||
*GFAP +ve -- required for Dx, may be patchy. | |||
*S-100 +ve -- cytoplasm, usu. diffuse. | |||
=Glioblastoma= | =Glioblastoma= | ||