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Difference between revisions of "Pediatric pathology"
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==Gastrointestinal pathology== | ==Gastrointestinal pathology== | ||
===Aganglionosis=== | |||
*[[AKA]] Hirschsprung disease. | |||
====General==== | |||
*Congenital. | |||
*Fixed by surgery. | |||
Pathology: | |||
*Parasympathetic ganglion cells in intramural and submucosal plexuses - not present.<ref name=pathcon_hirschsprung>URL: [[http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970813-0] [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970813-0]]. Accessed on: 11 January 2011.</ref> | |||
====Microscopic==== | |||
Features:<ref name=pathcon_hirschsprung/> | |||
*Ganglion cells missing in submucosal plexus and myenteric plexus. | |||
*+/-Submucosal fibrosis. | |||
====Stains==== | |||
*Acetylcholinesterase: abundant, disorganized, nerve fibers. | |||
*CD117. (???) | |||
Images: | |||
*[http://66.244.141.33/colorectal-Hirschsprung-disease Hirschsprung disease - collection (66.244.141.33)]. | |||
*[http://pathology.mc.duke.edu/research/Histo_course/myent_plexus.jpg Normal myenteric plexus (duke.edu)].<ref>URL: [http://pathology.mc.duke.edu/research/PTH225.html http://pathology.mc.duke.edu/research/PTH225.html]. Accessed on: 11 January 2011.</ref> | |||
===Meconium peritonitis=== | |||
====General==== | |||
*May be due to a number of causes: | |||
**Aganglionosis (Hirschsprung disease). | |||
**Meconium ileus. | |||
====Microscopic==== | |||
Features: | |||
*Brown granular material - '''key feature'''. | |||
*+/-Multinucleated giant cells. | |||
*Inflammatory infiltrate (PMNs, lymphocytes, plasma cells). | |||
Image: | |||
*[http://www.pathologyoutlines.com/caseofweek/case2008106image2.jpg Meconium peritonitis - gross (pathologyoutlines.com)]. | |||
===Necrotizing enterocolitis=== | ===Necrotizing enterocolitis=== | ||
====General==== | ====General==== | ||