Talk:Pediatric pathology

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Meconium peritonitis with remote perforation

Microscopic description

The sections show small bowel with bowel wall necrosis, focal calcification, perforation and extensive serosal, predominantly lymphoplasmcytic, inflammation. There is meconium within the bowel wall and on the serosal surface. Ganglion cells are present in normal numbers and have a normal distribution. The mucosa does not have crypt enlargement, or intracellular or extracellular accumulation of mucus.

Final diagnosis

Small bowel, ileum, resection - Meconium peritonitis. - Remote perforation, see comment.


The findings are consistent with a remote vascular injury. There are no histomorphologic findings to suggest Hirschsprung disease or cystic fibrosis.


Microscopic description

The sections show skin with a dermis that contains sheets of histocytes with abundant eosinophilic, focally vacuolated cytoplasm and occasional reniform nuclei and grooved nuclei. Foam cells and Touton giant cells are not identified. There are no eosinophils and no mitotic activity. The lesion extends to the deep margin and radial margin. The epidermis is thin, devoid of a cellular infiltrate and has normal maturation to the surface.

Immunohistochemical staining with CD163 and CD68 show marked granular positivity. CD1a and CD207 (Langerin) only stain scattered cells of the epidermis (normal Langerhans cells) and is interpreted as negative. Mac387 stained the cytoplasm of scattered dermal cells and is interpreted as negative.

Final diagnosis

Skin, scalp, biopsy - juvenile xanthogranuloma.