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Uterine carcinosarcoma (view source)
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# | '''Uterine carcinosarcoma''', also known as '''malignant mixed muellerian tumour''' (abbreviated '''MMMT'''), is an uncommon malignant [[Uterine tumours|uterine tumour]]. | ||
==General== | |||
* Associated with previous radiation exposure. | |||
* Metstasize as adenocarcinoma. | |||
* Aggressive/poor prognosis;<ref name=pmid15688674>{{Cite journal | last1 = Ivy | first1 = JJ. | last2 = Unger | first2 = JB. | title = Malignant mixed mullerian sarcomas of the uterus--the LSUHSC Shreveport experience. | journal = J La State Med Soc | volume = 156 | issue = 6 | pages = 324-6 | month = | year = | doi = | PMID = 15688674 }}</ref> in one series 5 year survival ~= 30-35%.<ref name=pmid14967435>{{Cite journal | last1 = Callister | first1 = M. | last2 = Ramondetta | first2 = LM. | last3 = Jhingran | first3 = A. | last4 = Burke | first4 = TW. | last5 = Eifel | first5 = PJ. | title = Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. | journal = Int J Radiat Oncol Biol Phys | volume = 58 | issue = 3 | pages = 786-96 | month = Mar | year = 2004 | doi = 10.1016/S0360-3016(03)01561-X | PMID = 14967435 }}</ref> | |||
*Considered to be a poorly differentiated endometrial carcinoma with metaplastic changes.<ref name=pmid19853898>{{Cite journal | last1 = D'Angelo | first1 = E. | last2 = Prat | first2 = J. | title = Uterine sarcomas: a review. | journal = Gynecol Oncol | volume = 116 | issue = 1 | pages = 131-9 | month = Jan | year = 2010 | doi = 10.1016/j.ygyno.2009.09.023 | PMID = 19853898 }}</ref> | |||
*Case reports of MMMT in [[ovary]] and [[fallopian tube]]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP428>{{Ref WMSP|428}}</ref> | |||
*Biphasic tumour: | |||
*#Malignant glandular component (adenocarcinoma). | |||
*#Malignant stromal component (one of the following): | |||
*#*Homologous type (tissue native to uterus): | |||
*#*#Smooth muscle ([[leiomyosarcoma]]). | |||
*#*#Fibrous tissue ([[fibrosarcoma]]). | |||
*#*Heterologous type (tissue not native to the uterus): | |||
*#*#Skeletal muscle ([[rhabdomyosarcoma]]). | |||
*#*#Cartilage ([[chondrosarcoma]]). | |||
*#*#Bone ([[osteosarcoma]]). | |||
*#*Undifferentiated sarcoma ([[pleomorphic undifferentiated sarcoma]]). | |||
DDx: | |||
*[[Undifferentiated endometrial sarcoma]]. | |||
*[[Adenosarcoma of the uterus]]. | |||
===Images=== | |||
<gallery> | |||
Image:Carcinosarcoma_-_low_mag.jpg | MMMT - low mag. (WC) | |||
Image:Carcinosarcoma_-_high_mag.jpg | MMMT - high mag. (WC) | |||
Image:MalignantMixedMullerianTumor.JPG | MMMT - crappy (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case227.html MMMT - case 1 - several images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case328.html MMMT - case 2 - several images (upmc.edu)]. | |||
==See also== | |||
*[[Uterine tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Gynecologic pathology]] | |||