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Difference between revisions of "Mesenchymal chondrosarcoma"
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Mesenchymal chondrosarcoma (view source)
Revision as of 11:26, 20 November 2014
, 11:26, 20 November 2014no edit summary
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==Microscopic== | ==Microscopic== | ||
'White clouds in a dark blue sky' | |||
*Malignant tumor with a characteristic biphasic pattern | *Malignant tumor with a characteristic biphasic pattern | ||
**Cellular poorly differentiated small round blue cells | **Cellular poorly differentiated small round blue cells | ||
**Can have a hemangiopericytomatous vascular pattern | |||
**Islands of well-differentiated hyaline cartilage | **Islands of well-differentiated hyaline cartilage | ||
***Progressive maturation of cartilage towards the center | ***Progressive maturation of cartilage towards the center | ||
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*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)]. | ||
*Web Pathology - This example evokes hemangiopericytoma [http://www.webpathology.com/images/noimage.gif]. | *Web Pathology - This example evokes hemangiopericytoma [http://www.webpathology.com/images/noimage.gif]. | ||
* | *Pathology Outlines - Another hemangiopericytomatous example [http://pathologyoutlines.com/wick/chondrosarcoma%20mesenchymal%20type%20micro0007.jpg] | ||
*Sarcoma Images - [http://www.sarcomaimages.com/index.php?v=Mesenchymal-Chondrosarcoma] | |||
*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_poIB6FYZQ73wh.jpg] | |||
*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_9oJtTQXXxaEB3.jpg] | |||
*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_8h2C7upeOj3EB.jpg] | |||
==IHC== | ==IHC== | ||
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*S100 (positive in chondrocytes not in small cells). | *S100 (positive in chondrocytes not in small cells). | ||
*Osteocalcin (negative in small cells). | *Osteocalcin (negative in small cells). | ||
==DDX== | |||
Depends a bit on where the tumor is located and how much cartilage is readily visible. | |||
**Hemangiopericytoma - no cartilage | |||
**Lymphoma - Sox9 negative, CD45 positive | |||
**Metaplastic Glioblastoma - usually older adults - GFAP positive | |||
**Chondrosarcoma - usually older adults - hyaline cartilage is malignant | |||
**Small cell osteosarcoma - Sox10 negative, no cartilage | |||
**Ewing sarcoma - Both are CD99 positive but ES is Sox9 negative, no cartilage | |||
==Molecular== | ==Molecular== | ||
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*[[Cartilage]]. | *[[Cartilage]]. | ||
*[[Chondrosarcoma]]. | *[[Chondrosarcoma]]. | ||
*Web Pathology[http://www.webpathology.com/image.asp?case=332&n=41] | |||
*Pathology Oulines [http://www.pathologyoutlines.com/topic/bonemesenchymalchondrosarcoma.html] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||