Mesenchymal chondrosarcoma

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Mesenchymal chondrosarcoma is a rare type of chondrosarcoma that is found in the soft tissue.


  • Rare variant of chondrosarcoma.
  • 2–10% of primary chondrosarcomas.
  • Adolescents and young adults.
  • Female predilection.
  • Most commonly intraosseous but can occur in extraskeletal sites especially the central nervous system (from the meninges).
  • The mesenchymal in the name refers to the ability to arise in soft tissues.[1]
  • Conceptualized as originating from a pleuripotential mesenchymal cell with foci recapitulating enchondral ossification.
  • The small cells appear to be an undifferentiated cartilage stem cell which “differentiate” into benign cartilage.[2]


Pink and fleshy with foci of calcification.




  • May be described as white clouds in a dark blue sky.



  • Depends a bit on where the tumour is located and how much cartilage is readily visible.




  • SOX9 (positive in small cells and chondrocytes).[3]
  • S100 (positive in chondrocytes not in small cells).
  • Osteocalcin (negative in small cells).
  • CD99 - (positive in small cells)


  • t(8;8)(q21.1;q13.3) HEY1-NCOA2.[4]
  • Less commonly t(1;5)(q42;q32) IRF2BP2-CDX1[5]

See also


  1. Dowling EA (June 1964). "Mesenchymal chondrosarcoma". J Bone Joint Surg Am 46: 747–54. PMID 14161087.
  2. Fanburg-Smith, JC.; Auerbach, A.; Marwaha, JS.; Wang, Z.; Rushing, EJ. (May 2010). "Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases.". Hum Pathol 41 (5): 653-62. doi:10.1016/j.humpath.2009.11.006. PMID 20138330.
  3. Pang, ZG.; He, XZ.; Wu, LY.; Wei, W.; Liu, XY.; Liao, DY.; Li, FY.; Zhang, XL. (Jun 2011). "[Clinicopathologic and immunohistochemical study of 23 cases of mesenchymal chondrosarcoma].". Zhonghua Bing Li Xue Za Zhi 40 (6): 368-72. PMID 21914343.
  4. Panagopoulos, I.; Gorunova, L.; Bjerkehagen, B.; Boye, K.; Heim, S. (Jul 2014). "Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma.". Oncol Rep 32 (1): 40-4. doi:10.3892/or.2014.3180. PMID 24839999.
  5. Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLoS ONE 7 (11): e49705. doi:10.1371/journal.pone.0049705. PMC 3504151. PMID 23185413. //

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