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Difference between revisions of "Oligodendroglioma"
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→IHC: tweak... think it is usu. -ve
(→IHC) |
(→IHC: tweak... think it is usu. -ve) |
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**Some subtypes +ve - should not be used to distinguish.<ref name=Ref_PSNP>{{Ref PSNP|98}}</ref> | **Some subtypes +ve - should not be used to distinguish.<ref name=Ref_PSNP>{{Ref PSNP|98}}</ref> | ||
*EMA +ve. | *EMA +ve. | ||
*IDH-1 +ve. | *IDH-1 -ve. | ||
**18% +ve in one series of children,<ref name=pmid24805856>{{Cite journal | last1 = Rodriguez | first1 = FJ. | last2 = Tihan | first2 = T. | last3 = Lin | first3 = D. | last4 = McDonald | first4 = W. | last5 = Nigro | first5 = J. | last6 = Feuerstein | first6 = B. | last7 = Jackson | first7 = S. | last8 = Cohen | first8 = K. | last9 = Burger | first9 = PC. | title = Clinicopathologic features of pediatric oligodendrogliomas: a series of 50 patients. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1058-70 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000221 | PMID = 24805856 }}</ref> 23% +ve in another series.<ref name=pmid23361281>{{Cite journal | last1 = Sipayya | first1 = V. | last2 = Sharma | first2 = I. | last3 = Sharma | first3 = KC. | last4 = Singh | first4 = A. | title = Immunohistochemical expression of IDH1 in gliomas: a tissue microarray-based approach. | journal = J Cancer Res Ther | volume = 8 | issue = 4 | pages = 598-601 | month = | year = | doi = 10.4103/0973-1482.106567 | PMID = 23361281 }}</ref> | |||
*p53 -ve. | *p53 -ve. | ||
**Useful for differentiating ''astrocytoma'' vs. ''oligodendroglioma''. | **Useful for differentiating ''astrocytoma'' vs. ''oligodendroglioma''. | ||