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Difference between revisions of "Chondromyxoid fibroma"
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Chondromyxoid fibroma (view source)
Revision as of 03:47, 14 November 2014
, 03:47, 14 November 2014no edit summary
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*Metaphyseal lesion - classic location.<ref name=pmid18312923>{{Cite journal | last1 = Budny | first1 = AM. | last2 = Ismail | first2 = A. | last3 = Osher | first3 = L. | title = Chondromyxoid fibroma. | journal = J Foot Ankle Surg | volume = 47 | issue = 2 | pages = 153-9 | month = | year = | doi = 10.1053/j.jfas.2007.08.013 | PMID = 18312923 }}</ref> | *Metaphyseal lesion - classic location.<ref name=pmid18312923>{{Cite journal | last1 = Budny | first1 = AM. | last2 = Ismail | first2 = A. | last3 = Osher | first3 = L. | title = Chondromyxoid fibroma. | journal = J Foot Ankle Surg | volume = 47 | issue = 2 | pages = 153-9 | month = | year = | doi = 10.1053/j.jfas.2007.08.013 | PMID = 18312923 }}</ref> | ||
*Well-circumscribed. | *Well-circumscribed. | ||
*Fragments of white-grey rubbery tissue | *Fragments of white-grey rubbery tissue. | ||
==Microscopic== | ==Microscopic== | ||
| Line 14: | Line 14: | ||
*Spindle cells or stellate cells in a myxoid or chondroid stroma. | *Spindle cells or stellate cells in a myxoid or chondroid stroma. | ||
*Lobules with hypocellular centers and hypercellular peripheries. | *Lobules with hypocellular centers and hypercellular peripheries. | ||
*Giant cells in the hypercellular periphery | *[[Giant cells]] in the hypercellular periphery. | ||
*Scattered calcifications | *Scattered calcifications. | ||
*No true hyaline cartilage formation | *No true hyaline cartilage formation. | ||
*No mitotic activity | *No mitotic activity. | ||
DDx: | DDx: | ||
*[[Phosphaturic mesenchymal tumour]] - case report.<ref>{{Cite journal | last1 = Suryawanshi | first1 = P. | last2 = Agarwal | first2 = M. | last3 = Dhake | first3 = R. | last4 = Desai | first4 = S. | last5 = Rekhi | first5 = B. | last6 = Reddy | first6 = KB. | last7 = Jambhekar | first7 = NA. | title = Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance. | journal = Skeletal Radiol | volume = 40 | issue = 11 | pages = 1481-5 | month = Nov | year = 2011 | doi = 10.1007/s00256-011-1159-6 | PMID = 21533894 }}</ref> | *[[Phosphaturic mesenchymal tumour]] - case report.<ref>{{Cite journal | last1 = Suryawanshi | first1 = P. | last2 = Agarwal | first2 = M. | last3 = Dhake | first3 = R. | last4 = Desai | first4 = S. | last5 = Rekhi | first5 = B. | last6 = Reddy | first6 = KB. | last7 = Jambhekar | first7 = NA. | title = Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance. | journal = Skeletal Radiol | volume = 40 | issue = 11 | pages = 1481-5 | month = Nov | year = 2011 | doi = 10.1007/s00256-011-1159-6 | PMID = 21533894 }}</ref> | ||
*[[Chondroblastoma]] | *[[Chondroblastoma]]. | ||
** | **Likewise has immature cartilage but (1) epiphyseal location, (2) chickenwire-like calcifications. | ||
*[[Chondrosarcoma]]. | |||
**Different age group. | |||
*[[Chondrosarcoma]] | **Mature hyaline cartilage formation. | ||
**Different age group | **Tumour permeation of the surrounding bone. | ||
**Mature hyaline cartilage formation | **Mitotic activity. | ||
** | |||
**Mitotic activity | |||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Bone ChondromyxoidFibroma HP2 PA (2).jpg|Stellate cells in a myxoid stroma. (SKB) | Image:Bone ChondromyxoidFibroma HP2 PA (2).jpg|Stellate cells in a myxoid stroma. (SKB) | ||
| Line 55: | Line 44: | ||
Image:Bone ChondromyxoidFibroma MP3 PA.JPG|Foci of amorphous calcification. (SKB) | Image:Bone ChondromyxoidFibroma MP3 PA.JPG|Foci of amorphous calcification. (SKB) | ||
</gallery> | </gallery> | ||
www: | |||
*[http://www.webpathology.com/image.asp?n=7&Case=331 Chondromyxoid fibroma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=331&n=8 Chondromyxoid fibroma - high mag. (webpathology.com)]. | |||
*Tumor Library [http://www.tumorlibrary.com/case/images/1490.jpg]. | |||
*Tumor Library [http://www.tumorlibrary.com/case/images/1491.jpg]. | |||
*Tumor Library [http://www.tumorlibrary.com/case/images/3618.jpg]. | |||
*Tumor Library [http://www.tumorlibrary.com/case/images/3619.jpg]. | |||
*Tumor Library [http://www.tumorlibrary.com/case/images/3621.jpg]. | |||
*Tumor Library [http://www.tumorlibrary.com/case/images/3623.jpg]. | |||
*Diagnostic Pathology [http://www.diagnosticpathology.org/content/figures/1746-1596-2-44-4.jpg]. | |||
==Molecular== | ==Molecular== | ||
*Activating rearrangements of GRM1 (metabotropic glutamate receptor 1)<ref>{{Cite journal | last1 = Nord | first1 = KH. | last2 = Lilljebjörn | first2 = H. | last3 = Vezzi | first3 = F. | last4 = Nilsson | first4 = J. | last5 = Magnusson | first5 = L. | last6 = Tayebwa | first6 = J. | last7 = de Jong | first7 = D. | last8 = Bovée | first8 = JV. | last9 = Hogendoorn | first9 = PC. | title = GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. | journal = Nat Genet | volume = 46 | issue = 5 | pages = 474-7 | month = May | year = 2014 | doi = 10.1038/ng.2927 | PMID = 24658000 }}</ref> | *Activating rearrangements of GRM1 (metabotropic glutamate receptor 1).<ref name=pmid24658000>{{Cite journal | last1 = Nord | first1 = KH. | last2 = Lilljebjörn | first2 = H. | last3 = Vezzi | first3 = F. | last4 = Nilsson | first4 = J. | last5 = Magnusson | first5 = L. | last6 = Tayebwa | first6 = J. | last7 = de Jong | first7 = D. | last8 = Bovée | first8 = JV. | last9 = Hogendoorn | first9 = PC. | title = GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. | journal = Nat Genet | volume = 46 | issue = 5 | pages = 474-7 | month = May | year = 2014 | doi = 10.1038/ng.2927 | PMID = 24658000 }}</ref> | ||
==See also== | ==See also== | ||
*[[Chondro-osseous tumours]]. | *[[Chondro-osseous tumours]]. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
==External links== | |||
*[http://njms2.umdnj.edu/tutorweb/case4.htm UMDNJ Tutor Web - Case (umdnj.edu)]. | |||
*[http://www.pathologyoutlines.com/topic/bonechondromyxoidfibroma.html Chondromyxoid fibroma (pathologyoutlines.com)]. | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Chondro-osseous tumours]] | [[Category:Chondro-osseous tumours]] | ||