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Difference between revisions of "Intravascular large B-cell lymphoma"
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Intravascular large B-cell lymphoma (view source)
Revision as of 06:51, 9 November 2014
, 06:51, 9 November 2014no edit summary
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Intravascular lymphoma - very high mag.jpg | |||
| Width = | |||
| Caption = Intravascular lymphoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = abundant atypical intravascular lymphoid cells (large ~2-3X size of a mature lymphocyte, nucleolus prominent) | |||
| Subtypes = | |||
| LMDDx = T-cell intravascular lymphoma | |||
| Stains = | |||
| IHC = CD45 +ve, CD20 +ve, CD34 -ve, CD3 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[blood vessels]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = non-specific presentation - may include fever, skin lesions | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Intravascular large B-cell lymphoma''' refers to a rare form of [[lymphoma]] that is intravascular, B-cell derived, and does not manifest as a mass. | '''Intravascular large B-cell lymphoma''' refers to a rare form of [[lymphoma]] that is intravascular, B-cell derived, and does not manifest as a mass. | ||
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==General== | ==General== | ||
*Rare - est. at one in million.<ref name=pmid22529262>{{Cite journal | last1 = Raza | first1 = M. | last2 = Qayyum | first2 = S. | last3 = Raza | first3 = S. | last4 = Goorha | first4 = S. | title = Intravascular B-cell lymphoma: an elusive diagnosis. | journal = J Clin Oncol | volume = 30 | issue = 15 | pages = e144-5 | month = May | year = 2012 | doi = 10.1200/JCO.2011.38.7720 | PMID = 22529262 }}</ref> | |||
Clinical: | Clinical: | ||
*Often a non-specific presentation.<ref name=pmid11579120>{{cite journal |author=Lapkuviene O, Forchetti D, Roepke JE |title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms |journal=J. Clin. Oncol. |volume=19 |issue=19 |pages=3988–91 |year=2001 |month=October |pmid=11579120 |doi= |url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref> | *Often a non-specific presentation.<ref name=pmid11579120>{{cite journal |author=Lapkuviene O, Forchetti D, Roepke JE |title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms |journal=J. Clin. Oncol. |volume=19 |issue=19 |pages=3988–91 |year=2001 |month=October |pmid=11579120 |doi= |url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref> | ||
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Features:<ref name=pmid11579120/> | Features:<ref name=pmid11579120/> | ||
*CD20 +ve - '''key feature'''. | *CD20 +ve - '''key feature'''. | ||
*CD79a +ve.<ref name=pmid22529262/> | |||
*CD3 -ve. | *CD3 -ve. | ||
*CD34 -ve. | *CD34 -ve. | ||