Difference between revisions of "Succinate dehydrogenase"

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'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain.  It is localized to the mitochondria.
'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain.  It is localized to the mitochondria.


Mutation-associated with pathology:
==Immunostain==
*It is used to look for mitochondrial disease.
*Loss of staining is pathologic.
 
==Associated pathology==
Mutations in SDH genes are associated with:
*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal  | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref>
*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal  | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref>
*[[Pheochromocytoma]].<ref name=pmid24500761/>
*[[Pheochromocytoma]].<ref name=pmid24500761/>
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