48,830
edits
Difference between revisions of "Desmoid-type fibromatosis"
Jump to navigation
Jump to search
Desmoid-type fibromatosis (view source)
Revision as of 06:47, 3 October 2014
, 06:47, 3 October 2014→Molecular
| Line 92: | Line 92: | ||
==Molecular== | ==Molecular== | ||
*Sporadic desmoids (~85%) | *Sporadic desmoids (~85%). | ||
** | **Point mutations in the CTNNB1 gene which encodes β-catenin. | ||
** | **Constitutively active β-catenin. | ||
*Syndromic desmoids (~5%) | *Syndromic desmoids (~5%): | ||
** | **Loss of function mutation in [[APC]]. | ||
** | **Loss of breakdown of β-catenin. | ||
** | **Constitutively active β-catenin. | ||
==Sign out== | ==Sign out== | ||