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Difference between revisions of "Desmoid-type fibromatosis"
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Desmoid-type fibromatosis (view source)
Revision as of 07:35, 2 October 2014
, 07:35, 2 October 2014no edit summary
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*DOG1 -ve. | *DOG1 -ve. | ||
*CD34 -ve. | *CD34 -ve. | ||
==Molecular== | |||
*Sporadic desmoids (~85%) | |||
**point mutations in the CTNNB1 gene which encodes β-catenin | |||
**constitutively active β-catenin | |||
*Syndromic desmoids (~5%) | |||
**loss of function mutation in APC | |||
**loss of breakdown of β-catenin | |||
**constitutively active β-catenin | |||
==Sign out== | ==Sign out== | ||
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*http://ghr.nlm.nih.gov/condition/desmoid-tumor | *http://ghr.nlm.nih.gov/condition/desmoid-tumor | ||
*http://atlasgeneticsoncology.org/Tumors/DesmoidFibromatosisID5179.html | *http://atlasgeneticsoncology.org/Tumors/DesmoidFibromatosisID5179.html | ||
*http://www.e-immunohistochemistry.info/web/beta-catenin.htm | |||
*http://surgpathcriteria.stanford.edu/softfib/extra-abdominal_desmoid_fibromatosis/differentialdiagnosis.html | |||
*http://www.pathologyoutlines.com/topic/softtissuefibromatosisdeep.html | |||
==References== | ==References== | ||