48,830
edits
Difference between revisions of "Immunohistochemical staining"
Jump to navigation
Jump to search
m
Immunohistochemical staining (view source)
Revision as of 03:10, 12 December 2010
, 03:10, 12 December 2010→Organ specific
m (→Neuropathology: fix ref) |
m (→Organ specific) |
||
| Line 40: | Line 40: | ||
==Organ specific== | ==Organ specific== | ||
===Thyroid=== | ===Thyroid and lung=== | ||
*TTF-1 ([[thyroid]] transcription factor-1) -- +ve in thyroid gland malignancies. | *TTF-1 ([[thyroid]] transcription factor-1) -- +ve in thyroid gland malignancies. | ||
**Very good for [[breast]] vs. [[lung]].<ref name=pmid18318581>{{cite journal |author=Jagirdar J |title=Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=384–96 |year=2008 |month=March |pmid=18318581 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=384}}</ref> | **Very good for [[breast]] vs. [[lung]].<ref name=pmid18318581>{{cite journal |author=Jagirdar J |title=Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=384–96 |year=2008 |month=March |pmid=18318581 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=384}}</ref> | ||
*** | ***Often negative in squamous cell carcinoma of the lung (as with CK7 & CK20), though HMWK is usually positive. | ||
Image: [http://commons.wikimedia.org/wiki/File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Adenocarcinoma with nuclear TTF-1 positivity (WC)]. | |||
===[[Breast]] markers=== | ===[[Breast]] markers=== | ||
*GCDFP-15 (aka BRST2) -- specific, but NOT sensitive. | *GCDFP-15 (aka BRST2) -- specific, but NOT sensitive. | ||