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Difference between revisions of "Esophageal adenocarcinoma"
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| Caption = Esophageal adenocarcinoma. [[H&E stain]]. | | Caption = Esophageal adenocarcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = "invading" cell clusters or glands (gland cribriforming (more than rare) or desmoplasia or submucosa invasion); nuclear atypia of malignancy (variation of size, shape, staining), +/-mitoses | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[high-grade columnar dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]],[[gastric adenocarcinoma]] | | LMDDx = [[high-grade columnar dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]],[[gastric adenocarcinoma]] | ||
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| Grossing = | | Grossing = | ||
| Site = | | Site = | ||
| Assdx = | | Assdx = [[Barrett's esophagus]], [[high-grade columnar dysplasia of the esophagus]] | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = often poor - as typically high stage at diagnosis | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = EMR (early), surgery - esophagectomy | ||
}} | }} | ||
'''Esophageal adenocarcinoma''', also '''adenocarcinoma of the esophagus''', is a common malignant epithelial-derived tumour of the distal esophagus, that classically arises in the context of [[Barrett's esophagus]]. | '''Esophageal adenocarcinoma''', also '''adenocarcinoma of the esophagus''', is a common malignant epithelial-derived tumour of the distal esophagus, that classically arises in the context of [[Barrett's esophagus]]. | ||
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*May be difficult to distinguish from adenocarcinoma of the stomach. | *May be difficult to distinguish from adenocarcinoma of the stomach. | ||
**By convention (in the ''[[CAP checklist]]'') gastroesophageal junction carcinomas are staged as esophageal carcinomas.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf]. Accessed on: 6 April 2012.</ref> | **By convention (in the ''[[CAP checklist]]'') gastroesophageal junction carcinomas are staged as esophageal carcinomas.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf]. Accessed on: 6 April 2012.</ref> | ||
Symptoms: | |||
*[[Dysphagia]]. | |||
Associations: | |||
*[[Barrett's esophagus]]. | |||
**[[Gastroesophageal reflux disease]]. | |||
*Hiatal hernia.<ref name=pmid24495377>{{cite journal |author=Jiang X, Tseng CC, Bernstein L, Wu AH |title=Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study |journal=BMC Cancer |volume=14 |issue= |pages=60 |year=2014 |pmid=24495377 |pmc=3915076 |doi=10.1186/1471-2407-14-60 |url=}}</ref> | |||
*Family history - [[prostate cancer]].<ref name=pmid24495377/> | |||
===Treatment=== | ===Treatment=== | ||