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Difference between revisions of "B cell small lymphocytic lymphoma/chronic lymphocytic leukemia"
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B cell small lymphocytic lymphoma/chronic lymphocytic leukemia (view source)
Revision as of 12:49, 10 June 2014
, 12:49, 10 June 2014no edit summary
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'''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. | '''B cell small lymphocytic lymphoma/chronic lymphocytic leukemia''', often referred to as '''chronic lymphocytic leukemia''' (abbreviated '''CLL''') or '''small lymphocytic lymphoma''' (abbreviated '''SLL'''), is a common low-grade hematologic [[malignancy]]. It typically afflicts older individuals. | ||
==General== | ==General== | ||
*Very common. | *Very common. | ||
*Good prognosis. | *Good prognosis - treatment may be simply followup.<ref name=pmid12676780>{{cite journal |author=Guarini A, Gaidano G, Mauro FR, ''et al.'' |title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features |journal=Blood |volume=102 |issue=3 |pages=1035–41 |year=2003 |month=August |pmid=12676780 |doi=10.1182/blood-2002-12-3639 |url=}}</ref> | ||
**May transform to an aggressive lymphoma - see below. | |||
*Older individuals. | |||
*Elevated WBC. | |||
===Richter's transformation=== | ===Richter's transformation=== | ||
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Others: | Others: | ||
*Cyclin D1 -ve. | *Cyclin D1 -ve. | ||
*CD38 -ve/+ve. | |||
**CD38 -ve suggests a good prognosis.<ref name=pmid12676780>{{cite journal |author=Guarini A, Gaidano G, Mauro FR, ''et al.'' |title=Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features |journal=Blood |volume=102 |issue=3 |pages=1035–41 |year=2003 |month=August |pmid=12676780 |doi=10.1182/blood-2002-12-3639 |url=}}</ref> | |||
==Molecular== | ==Molecular== | ||