Difference between revisions of "Kidney tumours"

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→‎Renal cell carcinoma with rhabdoid morphology
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===Renal cell carcinoma with rhabdoid morphology===
===Renal cell carcinoma with rhabdoid morphology===
*[[AKA]] ''renal cell carcinoma with rhabdoid change''.
*[[AKA]] ''renal cell carcinoma with rhabdoid change''.
====General====
{{Main|Renal cell carcinoma with rhabdoid morphology}}
*Not recognized as a distinct entity.<ref>{{Cite journal  | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref>
 
====Microscopic====
Features:
*[[Rhabdoid cells]]:
**Eccentrically placed large round nuclei with very prominent nucleoli.
**Abundant eosinophilic cytoplasm.
 
Notes:
*May be multinucleated.
 
====IHC====
Features:<ref name=pmid11023094>{{Cite journal  | last1 = Gökden | first1 = N. | last2 = Nappi | first2 = O. | last3 = Swanson | first3 = PE. | last4 = Pfeifer | first4 = JD. | last5 = Vollmer | first5 = RT. | last6 = Wick | first6 = MR. | last7 = Humphrey | first7 = PA. | title = Renal cell carcinoma with rhabdoid features. | journal = Am J Surg Pathol | volume = 24 | issue = 10 | pages = 1329-38 | month = Oct | year = 2000 | doi =  | PMID = 11023094 }}</ref>
*Vimentin +ve (23 of 23 cases).
*NSE +ve (~80% of cases).
*S-100 -ve/+ve (+ve ~ 40% of cases).
*Desmin -ve (23 of 23 cases).
*SMA -ve (~5% of cases).


==Hereditary renal cell carcinoma==
==Hereditary renal cell carcinoma==
Michael
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