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Difference between revisions of "Kidney tumours"
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→Renal cell carcinoma with sarcomatoid differentiation
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*[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal | last1 = Golshayan | first1 = AR. | last2 = George | first2 = S. | last3 = Heng | first3 = DY. | last4 = Elson | first4 = P. | last5 = Wood | first5 = LS. | last6 = Mekhail | first6 = TM. | last7 = Garcia | first7 = JA. | last8 = Aydin | first8 = H. | last9 = Zhou | first9 = M. | title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. | journal = J Clin Oncol | volume = 27 | issue = 2 | pages = 235-41 | month = Jan | year = 2009 | doi = 10.1200/JCO.2008.18.0000 | PMID = 19064974 }}</ref> | *[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal | last1 = Golshayan | first1 = AR. | last2 = George | first2 = S. | last3 = Heng | first3 = DY. | last4 = Elson | first4 = P. | last5 = Wood | first5 = LS. | last6 = Mekhail | first6 = TM. | last7 = Garcia | first7 = JA. | last8 = Aydin | first8 = H. | last9 = Zhou | first9 = M. | title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. | journal = J Clin Oncol | volume = 27 | issue = 2 | pages = 235-41 | month = Jan | year = 2009 | doi = 10.1200/JCO.2008.18.0000 | PMID = 19064974 }}</ref> | ||
*[http://www.scielo.br/img/revistas/ibju/v31n1/1a03f1.jpg Sarcomatoid changes in RCC (scielo.br)].<ref name=pmid15763002>{{Cite journal | last1 = Dall'Oglio | first1 = MF. | last2 = Lieberknecht | first2 = M. | last3 = Gouveia | first3 = V. | last4 = Sant'Anna | first4 = AC. | last5 = Leite | first5 = KR. | last6 = Srougi | first6 = M. | title = Sarcomatoid differentiation in renal cell carcinoma: prognostic implications. | journal = Int Braz J Urol | volume = 31 | issue = 1 | pages = 10-6 | month = | year = | doi = | PMID = 15763002 }}</ref> | *[http://www.scielo.br/img/revistas/ibju/v31n1/1a03f1.jpg Sarcomatoid changes in RCC (scielo.br)].<ref name=pmid15763002>{{Cite journal | last1 = Dall'Oglio | first1 = MF. | last2 = Lieberknecht | first2 = M. | last3 = Gouveia | first3 = V. | last4 = Sant'Anna | first4 = AC. | last5 = Leite | first5 = KR. | last6 = Srougi | first6 = M. | title = Sarcomatoid differentiation in renal cell carcinoma: prognostic implications. | journal = Int Braz J Urol | volume = 31 | issue = 1 | pages = 10-6 | month = | year = | doi = | PMID = 15763002 }}</ref> | ||
===Renal cell carcinoma with rhabdoid morphology=== | |||
*[[AKA]] ''renal cell carcinoma with rhabdoid change''. | |||
====General==== | |||
*Not recognized as a distinct entity.<ref>{{Cite journal | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref> | |||
====Microscopic==== | |||
Features: | |||
*[[Rhabdoid cells]]: | |||
**Eccentrically placed large round nuclei with very prominent nucleoli. | |||
**Abundant eosinophilic cytoplasm. | |||
Notes: | |||
*May be multinucleated. | |||
====IHC==== | |||
Features:<ref name=pmid11023094>{{Cite journal | last1 = Gökden | first1 = N. | last2 = Nappi | first2 = O. | last3 = Swanson | first3 = PE. | last4 = Pfeifer | first4 = JD. | last5 = Vollmer | first5 = RT. | last6 = Wick | first6 = MR. | last7 = Humphrey | first7 = PA. | title = Renal cell carcinoma with rhabdoid features. | journal = Am J Surg Pathol | volume = 24 | issue = 10 | pages = 1329-38 | month = Oct | year = 2000 | doi = | PMID = 11023094 }}</ref> | |||
*Vimentin +ve (23 of 23 cases). | |||
*NSE +ve (~80% of cases). | |||
*S-100 -ve/+ve (+ve ~ 40% of cases). | |||
*Desmin -ve (23 of 23 cases). | |||
*SMA -ve (~5% of cases). | |||
==Hereditary renal cell carcinoma== | ==Hereditary renal cell carcinoma== | ||