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Difference between revisions of "Glassy cell carcinoma"
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'''Glassy cell carcinoma''', abbreviated '''GCC''', is a rare [[malignancy]] of the [[uterine cervix]]. | |||
==General== | |||
*Rare. | |||
*Rapid growth, poor prognosis.<ref name=pmid19527406>{{Cite journal | last1 = Nasu | first1 = K. | last2 = Takai | first2 = N. | last3 = Narahara | first3 = H. | title = Multimodal treatment for glassy cell carcinoma of the uterine cervix. | journal = J Obstet Gynaecol Res | volume = 35 | issue = 3 | pages = 584-7 | month = Jun | year = 2009 | doi = 10.1111/j.1447-0756.2008.00968.x | PMID = 19527406 }}</ref> | |||
*Considered a subtype of [[adenosquamous carcinoma]].<ref name=pmid22384631>{{Cite journal | last1 = Kosińiska-Kaczyńska | first1 = K. | last2 = Mazanowska | first2 = N. | last3 = Bomba-Opoń | first3 = D. | last4 = Horosz | first4 = E. | last5 = Marczewska | first5 = M. | last6 = Wielgoś | first6 = M. | title = Glassy cell carcinoma of the cervix--a case report with review of the literature. | journal = Ginekol Pol | volume = 82 | issue = 12 | pages = 936-9 | month = Dec | year = 2011 | doi = | PMID = 22384631 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid11393075>{{Cite journal | last1 = Reis-Filho | first1 = JS. | last2 = Fillus Neto | first2 = J. | last3 = Schonemann | first3 = E. | last4 = Sanderson | first4 = A. | last5 = Schmitt | first5 = FC. | title = Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. | journal = Acta Cytol | volume = 45 | issue = 3 | pages = 407-10 | month = | year = | doi = | PMID = 11393075 }}</ref> | |||
*Epithelioid cells in sheets or cords. | |||
*Round/oval nucleus. | |||
*One or more prominent nucleoli. | |||
*Abundant finely vacuolated eosinophilic to amphophilic cytoplasm. | |||
*Distinct cell borders. | |||
*Inflammation - esp. eosinophils.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=561 http://www.webpathology.com/image.asp?n=2&Case=561]. Accessed on: 4 September 2011.</ref> | |||
DDx: | |||
*[[Adenosquamous carcinoma of the uterine cervix]]. | |||
*[[Squamous carcinoma of the uterine cervix]]. | |||
===Images=== | |||
<gallery> | |||
Image:Glassy_cell_carcinoma_-_low_mag.jpg | GCC - low mag. (WC) | |||
Image:Glassy_cell_carcinoma_-_intermed_mag.jpg | GCC - intermed. mag. (WC) | |||
Image:Glassy_cell_carcinoma_-_high_mag.jpg | GCC - high mag. (WC) | |||
Image:Glassy_cell_carcinoma_-_very_high_mag.jpg | GCC - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=1&Case=561 GCC - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=2&Case=561 GCC - high mag. (webpathology.com)]. | |||
*[http://path.upmc.edu/cases/case100/dx.html GCC - several images (upmc.edu)]. | |||
==Stains== | |||
*[[PAS stain]] - marks plasma membrane.<ref name=pmid15318016>{{Cite journal | last1 = Deshpande | first1 = AH. | last2 = Kotwal | first2 = MN. | last3 = Bobhate | first3 = SK. | title = Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. | journal = Indian J Cancer | volume = 41 | issue = 2 | pages = 92-5 | month = | year = | doi = | PMID = 15318016 | URL = http://www.indianjcancer.com/text.asp?2004/41/2/92/12353}}</ref> | |||
==See also== | |||
*[[Eosinophils]]. | |||
*[[Uterine cervix]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Uterine cervix]] | |||