Difference between revisions of "Chondro-osseous tumours"

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Chondro-osseous tumours (view source)

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→‎Chondroblastoma: split out
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==Chondroblastoma==
==Chondroblastoma==
===General===
{{Main|Chondroblastoma}}
*Growth plate lesion.
*Sclerotic margin.
*"Young" = growth plates open.
*Typically painful.<ref name=Ref_PCPBoD8_625>{{Ref PCPBoD8|625}}</ref>
 
===Gross===
*Well-defined lesion.
 
Image:
*[http://www.flickr.com/photos/35441329@N05/4052875138/in/set-72157622681280610 Chondroblastoma (flickr.com/humpath)].
 
===Microscopic===
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref>
*Abundant extracellular material - pink on [[H&E stain]] - looks vaguely like cartilage.
*Chondroblasts:
**Nuclear morphology variable: ovoid, folded or grooved.
**Moderate-abundant eosinophilic cytoplasm.
*+/-Calcification surrounds the cell nests ("chickenwire" appearance) - '''classic feature'''.
**Cell nests have a thin pale blue rimming.
*+/-[[Giant cells]].
**May lead to confusion with ''[[giant cell tumour of bone]]''.
 
DDx:
*[[Giant cell tumour of bone]].
*[[Chondroma]].
*Well-differentiated [[chondrosarcoma]].
 
====Images====
<gallery>
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC)
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC)
</gallery>
www:
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://path.upmc.edu/cases/case494/images/fig2a.jpg Chondroblastoma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case494.html http://path.upmc.edu/cases/case494.html]. Accessed on: 24 January 2012.</ref>
 
===IHC===
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref>
*S100 +ve.
*Vimentin +ve.<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>


==Chondromyxoid fibroma==
==Chondromyxoid fibroma==
Michael
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