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Intravascular large B-cell lymphoma (view source)
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'''Intravascular large B-cell lymphoma''' refers to a rare form of [[lymphoma]] that is intravascular, B-cell derived, and does not manifest as a mass. | |||
Several terms have been use to refer this entity, including '''angiotropic lymphoma''', '''intravascular malignant lymphomatosis''' and '''malignant angioendotheliomatosis'''. | |||
==General== | |||
Clinical: | |||
*Often a non-specific presentation.<ref name=pmid11579120>{{cite journal |author=Lapkuviene O, Forchetti D, Roepke JE |title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms |journal=J. Clin. Oncol. |volume=19 |issue=19 |pages=3988–91 |year=2001 |month=October |pmid=11579120 |doi= |url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref> | |||
**+/-Fever. | |||
**+/-Multiple infarcts. | |||
**+/-Non-specific skin lesions. | |||
==Microscopic== | |||
Features: | |||
*Abundant atypical intravascular lymphoid cells that are: | |||
**Large (~2-3X size of a mature lymphocyte or RBC). | |||
**Nucleolus prominent. | |||
Notes: | |||
*It may be hard to find RBCs in the vessels. | |||
*Looks sorta like a [[DLBCL]] -- but is intravascular. | |||
===Images=== | |||
<gallery> | |||
Image:Intravascular_lymphoma_-_high_mag.jpg | Intravascular lymphoma - high mag. (WC/Nephron) | |||
Image:Intravascular_lymphoma_-_very_high_mag.jpg | Intravascular lymphoma - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://jco.ascopubs.org/content/19/19/3988/F1.expansion.html ILBCL (ascopubs.org)].<ref name=pmid11579120/> | |||
*[http://theoncologist.alphamedpress.org/cgi/content/full/11/8/923/F1 ILBCL in bone marrow (alphamedpress.org)]. | |||
*[http://annonc.oxfordjournals.org/content/13/9/1503/F1.expansion.html ILBCL - various images (oxfordjournals.org)]. | |||
*[http://path.upmc.edu/cases/case473/images/fig01a.jpg ILBCL (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case473.html http://path.upmc.edu/cases/case473.html]. Accessed on: 21 January 2012.</ref> | |||
*[http://path.upmc.edu/cases/case697.html ILBCL - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=pmid11579120/> | |||
*CD20 +ve - '''key feature'''. | |||
*CD3 -ve. | |||
*CD34 -ve. | |||
==See also== | |||
*[[Intravascular lymphoma]]. | |||
*[[Lymphoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Lymphoma]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||