48,830
edits
Difference between revisions of "Juvenile granulosa cell tumour"
Jump to navigation
Jump to search
Juvenile granulosa cell tumour (view source)
Revision as of 03:49, 18 February 2014
, 03:49, 18 February 2014split out
(redirect) |
(split out) |
||
| Line 1: | Line 1: | ||
'''Juvenile granulosa cell tumour''' is an uncommon [[ovarian tumour]] in the ''sex cord stromal tumours'' group. | |||
==General== | |||
*May secrete estrogen. | |||
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | |||
**May present as precocious puberty.<ref name=pmid21526089>{{Cite journal | last1 = Hashemipour | first1 = M. | last2 = Moaddab | first2 = MH. | last3 = Nazem | first3 = M. | last4 = Mahzouni | first4 = P. | last5 = Salek | first5 = M. | title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. | journal = J Res Med Sci | volume = 15 | issue = 4 | pages = 240-2 | month = Jul | year = 2010 | doi = | PMID = 21526089 }}</ref> | |||
*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref> | |||
==Gross== | |||
*Classically solid. | |||
==Microscopic== | |||
Features: | |||
*Microcystic spaces. | |||
*Moderate-to-marked nuclear atypia. | |||
*Cuboidal-to-polygonal cell in sheets or stands or cords. | |||
*Basophilic cytoplasm. | |||
Notes: | |||
*Juvenile variant of GCT has more nuclear pleomorphism. | |||
===Images=== | |||
<gallery> | |||
Image:Juvenile_granulosa_cell_tumour_-_intermed_mag.jpg | Juvenile granulosa cell tumour - intermed. mag. (WC) | |||
Image:Juvenile_granulosa_cell_tumour_-_high_mag.jpg | Juvenile granulosa cell tumour - high mag. (WC) | |||
Image:Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg | Juvenile granulosa cell tumour - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
* Inhibin positive.<ref name=Ref_PBoD1102>{{Ref PBoD|1102}}</ref> | |||
** Inhibin negative in ''[[Brenner tumour]]''. | |||
*Calretinin +ve. | |||
==Molecular== | |||
:''Currently '''not''' used for the diagnosis.'' | |||
*Trisomy 12.<ref name=pmid1466394>{{Cite journal | last1 = Schofield | first1 = DE. | last2 = Fletcher | first2 = JA. | title = Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material. | journal = Am J Pathol | volume = 141 | issue = 6 | pages = 1265-9 | month = Dec | year = 1992 | doi = | PMID = 1466394 }}</ref><ref name=pmid12218213>{{Cite journal | last1 = Mayr | first1 = D. | last2 = Kaltz-Wittmer | first2 = C. | last3 = Arbogast | first3 = S. | last4 = Amann | first4 = G. | last5 = Aust | first5 = DE. | last6 = Diebold | first6 = J. | title = Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors. | journal = Mod Pathol | volume = 15 | issue = 9 | pages = 951-7 | month = Sep | year = 2002 | doi = 10.1097/01.MP.0000024290.55261.14 | PMID = 12218213 }} | |||
</ref> | |||
==See also== | |||
*[[Ovarian tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Ovarian tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||