Difference between revisions of "Breast pathology"

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Breast pathology (view source)

Revision as of 20:33, 16 February 2014

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→‎Collagenous spherulosis: split out
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==Collagenous spherulosis==
==Collagenous spherulosis==
*[[AKA]] ''mucinous spherulosis'', [[AKA]] ''spherulosis''.<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref>
*[[AKA]] ''mucinous spherulosis'', [[AKA]] ''spherulosis''.<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref>
===General===
{{Main|Collagenous spherulosis}}
*Benign.
*Almost always an incidental finding.
*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal  | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi =  | PMID = 16330938 }}</ref>
**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>
 
===Microscopic===
Features:<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref><ref>URL: [http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm]. Accessed on: 31 August 2011.</ref>
*Tubular/cribriform architecture.
*Intratubular eosinophilic material - '''key feature'''.
**Classical: Arranged like the spokes of a wheel ("radial spikes").
**Atypical: Granules ~ 1-2 micrometers.
*No mitotic activity.
*Two cells populations (epithelial & myoepithelial) - like a well-behaved breast gland.
 
Notes:
*Usually small lesions: < 50 spherules per lesion, <100 micrometers.
*May be multifocal.
*+/-Calcifications - may prompt biopsy.
 
DDx:
*[[Atypical ductal hyperplasia]].
*[[Cribriform DCIS]].
*[[Adenoid cystic carcinoma of the breast]].
 
====Images====
<gallery>
Image:Collagenous_spherulosis_-_intermed_mag.jpg | Collagenous spherulosis - intermed. mag. (WC/Nephron)
Image:Collagenous_spherulosis_-_very_high_mag.jpg | Collagenous spherulosis - very high mag. (WC/Nephron)
</gallery>
www:
*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)].


==Nipple adenoma==
==Nipple adenoma==
Michael
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