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Difference between revisions of "Adenomyoepithelioma"
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'''Adenomyoepithelioma''' is an uncommon pathology of the [[breast]]. It is usually benign. | |||
==General== | |||
*Rare lesion consisting of epithelial and myoepithelial elements. | |||
**May occur in other sites, e.g. tonsil.<ref name=pmid20356364>{{Cite journal | last1 = Ren | first1 = J. | last2 = Song | first2 = L. | last3 = Dang | first3 = Q. | last4 = Zhang | first4 = X. | last5 = Jiang | first5 = SW. | last6 = Zhang | first6 = G. | last7 = Wang | first7 = N. | last8 = Liu | first8 = Z. | last9 = Wang | first9 = J. | title = Primary adenomyoepithelioma of tonsil. | journal = Head Neck Oncol | volume = 2 | issue = | pages = 7 | month = | year = 2010 | doi = 10.1186/1758-3284-2-7 | PMID = 20356364 }}</ref> | |||
*May be benign or malignant.<ref name=pmid12591699>{{Cite journal | last1 = Howlett | first1 = DC. | last2 = Mason | first2 = CH. | last3 = Biswas | first3 = S. | last4 = Sangle | first4 = PD. | last5 = Rubin | first5 = G. | last6 = Allan | first6 = SM. | title = Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology. | journal = AJR Am J Roentgenol | volume = 180 | issue = 3 | pages = 799-803 | month = Mar | year = 2003 | doi = | PMID = 12591699 | url=http://www.ajronline.org/content/180/3/799.full}}</ref><ref name=pmid19480267>{{Cite journal | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Vasilakaki | first2 = T. | last3 = Grammatoglou | first3 = X. | last4 = Petrakopoulou | first4 = N. | last5 = Nikolaidou | first5 = ME. | last6 = Glava | first6 = C. | title = Malignant adenomyoepithelioma of the breast--case report. | journal = Eur J Gynaecol Oncol | volume = 30 | issue = 2 | pages = 234-6 | month = | year = 2009 | doi = | PMID = 19480267 }}</ref> | |||
Note: | |||
*Possibly the same tumour as [[epithelial-myoepithelial carcinoma]] of the [[salivary gland]].<ref name=pmid9769134>{{Cite journal | last1 = Seifert | first1 = G. | title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? | journal = Virchows Arch | volume = 433 | issue = 3 | pages = 285-8 | month = Sep | year = 1998 | doi = | PMID = 9769134 }}</ref> | |||
==Microscopic== | |||
Features:<ref>URL: [http://www.webpathology.com/image.asp?n=1&Case=322 http://www.webpathology.com/image.asp?n=1&Case=322]. Accessed on: 16 August 2011.</ref> | |||
*Well-circumscribed. | |||
*Glandular architecture with: | |||
**Easily identifiable myoepithelial cells - with clear cytoplasm - '''key feature'''. | |||
**Eosinophilic cuboidal epithelial cells. | |||
*Eosinophilic basement membrane material between glands. | |||
DDx: | |||
*[[Invasive ductal carcinoma of the breast]] (on core biopsy). | |||
*Mammary pleomorphic adenoma. | |||
*Ductal adenoma. | |||
*[[Tubular adenoma of the breast]] - does not have a prominent (clear) myoepithelial component. | |||
*[[Sclerosing adenosis]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Adenomyoepithelioma_-_low_mag.jpg | Adenomyoepithelioma - low mag. (WC/Nephron) | |||
Image:Adenomyoepithelioma_-_intermed_mag.jpg | Adenomyoepithelioma - intermed. mag. (WC/Nephron) | |||
Image:Adenomyoepithelioma_-_high_mag.jpg | Adenomyoepithelioma - high mag. (WC/Nephron) | |||
</gallery> | |||
Webpathology.com: | |||
*[http://www.webpathology.com/image.asp?n=1&Case=322 Adenomyoepithelioma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=4&Case=322 Adenomyoepithelioma - high mag. (webpathology.com)]. | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||