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Microglandular adenosis (view source)
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'''Microglandular adenosis''', abbreviated '''MGA''', is a benign pathology of the [[breast]]. | |||
'''''Not''' to be confused with [[microglandular hyperplasia]]''. | |||
==General== | |||
*Controversial thingy. | |||
Management: | |||
*Excision. | |||
==Microscopic== | |||
Features:<ref name=uscap_mga>URL: [http://www.uscap.org/site~/iap2006/slides08-4v.htm http://www.uscap.org/site~/iap2006/slides08-4v.htm]. Accessed on: 18 May 2011.</ref> | |||
*Round glands lined by a single layer of cells. | |||
*May extend into fat. | |||
*Lack of desmoplastic stroma. | |||
DDx: | |||
*[[Tubular carcinoma]] - has apical snouts, desmoplasia among other things; see page by ''Collins''.<ref name=uscap_mga>URL: [http://www.uscap.org/site~/iap2006/slides08-4v.htm http://www.uscap.org/site~/iap2006/slides08-4v.htm]. Accessed on: 18 May 2011.</ref> | |||
*[[Sclerosing adenosis]]. | |||
===Images=== | |||
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=1&s=20080802171452955&i=0&p=0 Microglandular adenosis (surgical pathologyatlas.com)]. | |||
*[http://webpathology.com/image.asp?n=1&Case=282 MGA - low mag. (webpathology.com)]. | |||
*[http://webpathology.com/image.asp?n=2&Case=282 MGA - high mag. (webpathology.com)]. | |||
*[http://www.breastpathology.info/Images/Benign/SclerAdenosis/mga1c_400.jpg MGA (breastpathology.info)]. | |||
*[http://www.breastpathology.info/sub-pages-iotw/2010/2.html MGA - several images (breastpathology.info)]. | |||
==IHC== | |||
Features:<ref name=pmid8821958>{{Cite journal | last1 = Joshi | first1 = MG. | last2 = Lee | first2 = AK. | last3 = Pedersen | first3 = CA. | last4 = Schnitt | first4 = S. | last5 = Camus | first5 = MG. | last6 = Hughes | first6 = KS. | title = The role of immunocytochemical markers in the differential diagnosis of proliferative and neoplastic lesions of the breast. | journal = Mod Pathol | volume = 9 | issue = 1 | pages = 57-62 | month = Jan | year = 1996 | doi = | PMID = 8821958 }}</ref> | |||
*S100 +ve. | |||
*34BE12 +ve -- focal! | |||
Others: | |||
*EMA -ve. | |||
**Tubular carcinoma usu. +ve. | |||
*[[GCDFP-15]] -ve.<ref>{{Ref APBR|296 Q20}}</ref> | |||
*Ki-67 <3%. | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Breast pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||