Microglandular adenosis

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Microglandular adenosis, abbreviated MGA, is a benign pathology of the breast.

Not to be confused with microglandular hyperplasia.

General

  • Controversial thingy.

Management:

  • Excision.

Microscopic

Features:[1]

  • Round glands lined by a single layer of cells.
  • May extend into fat.
  • Lack of desmoplastic stroma.

DDx:

Images

IHC

Features:[2]

  • S100 +ve.
  • 34BE12 +ve -- focal!

Others:

  • EMA -ve.
    • Tubular carcinoma usu. +ve.
  • GCDFP-15 -ve.[3]
  • Ki-67 <3%.

See also

References

  1. 1.0 1.1 URL: http://www.uscap.org/site~/iap2006/slides08-4v.htm. Accessed on: 18 May 2011.
  2. Joshi, MG.; Lee, AK.; Pedersen, CA.; Schnitt, S.; Camus, MG.; Hughes, KS. (Jan 1996). "The role of immunocytochemical markers in the differential diagnosis of proliferative and neoplastic lesions of the breast.". Mod Pathol 9 (1): 57-62. PMID 8821958.
  3. Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 296 Q20. ISBN 978-1416025887.