48,830
edits
Difference between revisions of "Low-grade squamous intraepithelial lesion"
Jump to navigation
Jump to search
Low-grade squamous intraepithelial lesion (view source)
Revision as of 12:25, 31 January 2014
, 12:25, 31 January 2014→Microscopic
| Line 71: | Line 71: | ||
Features:<ref name=Ref_PBoD1075-6>{{Ref PBoD|1075-6}}</ref> | Features:<ref name=Ref_PBoD1075-6>{{Ref PBoD|1075-6}}</ref> | ||
*"Koilocytic atypia":<ref name=Ref_GP146>{{Ref GP|146}}</ref> | *"Koilocytic atypia":<ref name=Ref_GP146>{{Ref GP|146}}</ref> | ||
** | **Clear cytoplasmic halos (perinuclear clearing). | ||
**Nuclear enlargement >=3:1 enlarged nucleus:normal nucleus. | **Nuclear enlargement. | ||
**Nuclear membrane irregularities. | ***Classically >=3:1 enlarged nucleus:normal nucleus. | ||
**Nuclear hyperchromasia. | ***May be mild (superficial cells = size of basal cells). | ||
**Nuclear membrane irregularities - '''important'''. | |||
**Nuclear hyperchromasia - '''important'''. | |||
**Coarse chromatin. | **Coarse chromatin. | ||
**Binucleation may be seen (cytopathic effect of [[HPV]]).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref> | **+/-Binucleation may be seen (cytopathic effect of [[HPV]]).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref> | ||
***Useful when present. | |||
Note: | Note: | ||
| Line 91: | Line 94: | ||
Koilocytes: | Koilocytes: | ||
*Perinuclear clearing. | *Perinuclear clearing. | ||
*Nuclear changes. | **Halo should be crystal clear. | ||
*Nuclear changes - '''key feature'''. | |||
**Size similar (or larger) to those in the basal layer of the epithelium. | **Size similar (or larger) to those in the basal layer of the epithelium. | ||
**Nuclear enlargement should be evident on low power, i.e. 25x. <ref>V. Dube 2008.</ref> | ***Nuclear enlargement should be evident on low power, i.e. 25x.<ref>V. Dube 2008.</ref> | ||
**Central location - nucleus should be | **Nuclear hyperchromasia. | ||
**Central location - nucleus should be in the middle of the cell. | |||
***Benign cells have a small nucleus that is peripheral. | |||
===Images=== | ===Images=== | ||