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Difference between revisions of "Urothelium"
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→Papillary urothelial lesions
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*[[AKA]] ''high-grade papillary urothelial cell carcinoma'', abbreviated ''HGPUCC''. | *[[AKA]] ''high-grade papillary urothelial cell carcinoma'', abbreviated ''HGPUCC''. | ||
{{Main|High-grade papillary urothelial carcinoma}} | {{Main|High-grade papillary urothelial carcinoma}} | ||
==Papillary urothelial hyperplasia== | |||
*[[AKA]] ''papillary hyperplasia''. | |||
*[[AKA]] ''reactive papillary hyperplasia''. | |||
===General=== | |||
*Benign. | |||
*Strong association with papillary neoplasms. | |||
**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref> | |||
===Microscopic=== | |||
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | |||
*Inflammation. | |||
*Rare papillae | |||
**Do not have a well-developed fibrovascular core. | |||
*No urothelial cell atypia. | |||
Image: | |||
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)]. | |||
===Sign out=== | |||
<pre> | |||
URINARY BLADDER, BIOPSY: | |||
- REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT. | |||
- NO MUSCULARIS PROPRIA IDENTIFIED. | |||
- CYSTITIS CYSTICA ET GLANDULARIS. | |||
- NO EVIDENCE OF MALIGNANCY. | |||
COMMENT: | |||
The urothelial forms rare papillary structures; these are interpreted as reactive. | |||
The urothelium stains as follow: | |||
CK7: positive (patchy). | |||
CK20: very rare superficial cells (normal). | |||
Ki-67: rare, focally increased, negative in papillary structures (<10%). | |||
p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). | |||
Follow-up is recommended. | |||
</pre> | |||
=Benign urothelial lesions= | =Benign urothelial lesions= | ||