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Difference between revisions of "Urothelial dysplasia"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = low-grade urothelial dysplasia | |||
| Micro = mild nuclear enlargement (~3x a resting lymphocyte) and hyperchromasia, mild disorganization of the architecture (some maturation), occasional mitotic figures - none atypical | |||
| Subtypes = | |||
| LMDDx = reactive changes, [[urothelial carcinoma in situ]] | |||
| Stains = | |||
| IHC = CK20 +ve/-ve (esp. non-umbrella cells), Ki-67 +ve/-ve (>10%), p53 +ve/-ve (>20%) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urothelium]] (renal pelvis, [[urinary bladder]], [[ureters]], [[urethra]]) | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = pre-malignant | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Urothelial dysplasia''', also '''low-grade (urothelial) dysplasia''', is a lesion of the [[urothelium]] in the ISUP/WHO 2004 classification.<ref name=pmid19762067>{{Cite journal | last1 = Hodges | first1 = KB. | last2 = Lopez-Beltran | first2 = A. | last3 = Davidson | first3 = DD. | last4 = Montironi | first4 = R. | last5 = Cheng | first5 = L. | title = Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features. | journal = Hum Pathol | volume = 41 | issue = 2 | pages = 155-62 | month = Feb | year = 2010 | doi = 10.1016/j.humpath.2009.07.002 | PMID = 19762067 }}</ref> | '''Urothelial dysplasia''', also '''low-grade (urothelial) dysplasia''', is a lesion of the [[urothelium]] in the ISUP/WHO 2004 classification.<ref name=pmid19762067>{{Cite journal | last1 = Hodges | first1 = KB. | last2 = Lopez-Beltran | first2 = A. | last3 = Davidson | first3 = DD. | last4 = Montironi | first4 = R. | last5 = Cheng | first5 = L. | title = Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features. | journal = Hum Pathol | volume = 41 | issue = 2 | pages = 155-62 | month = Feb | year = 2010 | doi = 10.1016/j.humpath.2009.07.002 | PMID = 19762067 }}</ref> | ||