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Clear cell papillary renal cell tumour (view source)
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'''Clear cell papillary renal cell carcinoma''', abbreviated '''CCPRCC''', is recently described type of [[renal cell carcinoma]]. | |||
It is also known as '''clear cell tubulopapillary renal cell carcinoma'''.<ref name=pmid21602815>{{Cite journal | last1 = Rohan | first1 = SM. | last2 = Xiao | first2 = Y. | last3 = Liang | first3 = Y. | last4 = Dudas | first4 = ME. | last5 = Al-Ahmadie | first5 = HA. | last6 = Fine | first6 = SW. | last7 = Gopalan | first7 = A. | last8 = Reuter | first8 = VE. | last9 = Rosenblum | first9 = MK. | title = Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1207-20 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.80 | PMID = 21602815 }}</ref> | |||
==General== | |||
*New entity not in the WHO classification. | |||
==Microscopic== | |||
Features:<ref name=pmid21602815/> | |||
*Features of both: | |||
*#Clear cell RCC. | |||
*#Papillary RCC. | |||
*#*Often do not have true papillae. | |||
*Apical nuclei - '''key feature'''.<ref>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Tomaszewski | first2 = JE. | title = Case Report: Clear Cell Papillary Renal Cell Carcinoma in the Bilateral Native Kidneys after 2 Years of Renal Transplantation: Report of a Case and Review of the Literature. | journal = Case Reports in Transplantation | volume = 2011 | issue = | pages = | month = | year = 2011 | doi = 10.1155/2011/387645 | PMID = | url = http://www.hindawi.com/crim/transplantation/2011/387645/cta/ }}</ref> | |||
**In most glandular structures the nuclei are usu. basally located, i.e. in the cytoplasm adjacent to the basement membrane. | |||
DDx: | |||
*[[Papillary renal cell carcinoma]]. | |||
*[[Clear cell renal cell carcinoma]] | |||
*[[Xp11.2 translocation carcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Clear_cell_papillary_renal_cell_carcinoma_-_high_mag.jpg | CCPRCC - high mag. (WC/Nephron) | |||
Image:Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | CCPRCC - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case682.html Clear cell papillary RCC - several images (upmc.edu)]. | |||
*[http://www.flickr.com/photos/40764007@N08/7177459461/ CCPRCC (flickr.com)]. | |||
==IHC== | |||
Features:<ref name=pmid21602815/> | |||
*CK7 +ve. | |||
**Usually -ve in clear cell RCC. | |||
*CD10 -ve. | |||
**Usually +ve in clear cell RCC. | |||
**Positive in Xp11.2 translocation carcinoma.<ref name=pmid21804394>{{Cite journal | last1 = He | first1 = H. | last2 = Zhou | first2 = GX. | last3 = Zhou | first3 = M. | last4 = Chen | first4 = L. | title = The distinction of clear cell carcinoma of the female genital tract, clear cell renal cell carcinoma, and translocation-associated renal cell carcinoma: an immunohistochemical study using tissue microarray. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 425-30 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214dd4f | PMID = 21804394 }}</ref> | |||
*TFE3 -ve. | |||
**By definition +ve in [[Xp11.2 translocation carcinoma]]. | |||
*AMACR -ve. | |||
**Usu. +ve in [[Papillary RCC]]. | |||
*Smooth muscle actin +ve (focal).<ref name=pmid23238627>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Eble | first2 = JN. | last3 = Cheng | first3 = L. | last4 = Grignon | first4 = DJ. | title = Clear cell papillary renal cell carcinoma: differential diagnosis and extended immunohistochemical profile. | journal = Mod Pathol | volume = 26 | issue = 5 | pages = 697-708 | month = May | year = 2013 | doi = 10.1038/modpathol.2012.204 | PMID = 23238627 }}</ref> | |||
Others:<ref name=pmid21602815/> | |||
*HIF-1alpha +ve. | |||
*GLUT-1 +ve. | |||
How to remember: ''The two key stains are opposite of what the name implies''. | |||
*''Clear cell'' RCC: CK7 negative. In this tumour it is the opposite - CK7 is positive. | |||
*''Papillary'' RCC: AMACR positive. In this tumour it is the opposite - AMACR is negative. | |||
==See also== | |||
*[[Kidney tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Kidney tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||