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Difference between revisions of "Necrobiosis lipoidica"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Necrobiosis_lipoidica_-_low_mag.jpg | |||
| Width = | |||
| Caption = Necrobiosis lipoidica. [[HPS stain]]. | |||
| Micro = (dermal) palisading [[granuloma]] around necrotic collagen; little mucin; no normal dermis between foci; plasma cells - common; | |||
+/-involve subcutis | |||
| Subtypes = | |||
| LMDDx = [[granuloma annulare]], [[rheumatoid nodule]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = | |||
| Assdx = [[diabetes mellitus]], [[rheumatoid arthritis]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Necrobiosis lipoidica''' is an uncommon granulomatous [[skin]] pathology. | |||
==General== | |||
Associated with: | |||
*[[Diabetes mellitus]] - known as ''necrobiosis lipoidica diabeticorum''. | |||
*[[Rheumatoid arthritis]]. | |||
==Gross== | |||
Image: | |||
<gallery> | |||
Image:Necrobiosislipoidica.jpg | Necrobiosis lipoidica. (WC) | |||
</gallery> | |||
==Microscopic== | |||
Features:<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> | |||
*Dermal palisading [[granuloma]] around: | |||
**Necrotic collagen - '''key feature'''. | |||
***Nuclei "missing" - have undergone karyolysis. | |||
*Little mucin, no normal dermis between foci. | |||
*Plasma cells - common.<ref name=dermnetnz_nl>URL: [http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html]. Accessed on: 24 January 2012.</ref> | |||
*May involve adipose tissue. | |||
DDx: | |||
*[[Granuloma annulare|Granuloma a'''nn'''ulare]] - '''m'''ore '''m'''ucin, normal dermis between foci,<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> plasma cells uncommon,<ref name=dermnetnz_nl/> no fat involvement - usu. more superficial. | |||
*[[Rheumatoid nodule]]. | |||
===Images=== | |||
<gallery> | |||
Image:Necrobiosis_lipoidica_-_low_mag.jpg | Necrobiosis lipoidica - low mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://dermatology.cdlib.org/103/NYU/case_presentations/042004n10.html Necrobiosis lipoidica (dermatology.cdlib.org)]. | |||
*[http://www.drmihm.com/cases/case.cfm?CaseID=53 Necrobiosis lipoidica (drmihm.com)]. | |||
*[http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html Necrobiosis lipoidica (dermnetnz.org)]. | |||
==See also== | |||
*[Non-malignant skin disease]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||