|
|
Line 24: |
Line 24: |
|
| |
|
| ===Large epithelioid tumours=== | | ===Large epithelioid tumours=== |
| The following is an exhaustive [[DDx]] for a ''large epithelioid tumour''.
| | An exhaustive [[DDx]] for a ''large epithelioid tumour'' is in ''[[large epithelioid tumours]]''. |
| | |
| {| class="wikitable sortable"
| |
| ! Tumour
| |
| ! Group
| |
| ! Notes/comments
| |
| |-
| |
| | [[Melanoma]]
| |
| | Miscellaneous
| |
| |
| |
| |-
| |
| | [[PEComa]]
| |
| | Miscellaneous
| |
| | esp. [[epithelioid angiomyolipoma]]
| |
| |-
| |
| | [[Perivascular epithelioid cell sarcoma]]
| |
| | Miscellaneous
| |
| | type of PEComa, looks like clear cell carcinoma<ref name=pmid11406657>{{Cite journal | last1 = Bonetti| first1 = F.| last2 = Martignoni| first2 = G.| last3 = Colato| first3 = C.| last4 = Manfrin| first4 = E.| last5 = Gambacorta| first5 = M.| last6 = Faleri| first6 = M.| last7 = Bacchi| first7 = C.| last8 = Sin| first8 = VC.| last9 = Wong| first9 = NL.| title = Abdominopelvic sarcoma of perivascular epithelioid cells. Report of four cases in young women, one with tuberous sclerosis.| journal = Mod Pathol| volume = 14| issue = 6| pages = 563-8| month = Jun| year = 2001| doi = 10.1038/modpathol.3880351| PMID = 11406657 }}</ref>
| |
| |-
| |
| | [[Paraganglioma-like dermal melanocytic tumour]]
| |
| | Miscellaneous
| |
| | <ref name=pmid15577676>{{Cite journal | last1 = Deyrup| first1 = AT.| last2 = Althof| first2 = P.| last3 = Zhou| first3 = M.| last4 = Morgan| first4 = M.| last5 = Solomon| first5 = AR.| last6 = Bridge| first6 = JA.| last7 = Weiss| first7 = SW.| title = Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma.| journal = Am J Surg Pathol| volume = 28| issue = 12| pages = 1579-86| month = Dec| year = 2004| doi = | PMID = 15577676 }}</ref>
| |
| |-
| |
| | [[Carcinoma]]
| |
| | Epithelial tumours
| |
| |HCC and adrenal cortical carcinoma, often AE1/AE3 -ve
| |
| |-
| |
| | [[Hepatoid Adenocarcinoma]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Malignant mixed Muellerian tumour]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Myoepithelial carcinoma]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Myoepithelioma of soft tissue]]
| |
| | Epithelial tumours
| |
| | may mimic [[extraskeletal myxoid chondrosarcoma]] or proximal variant of [[epithelial sarcoma]]
| |
| |-
| |
| | [[Acinar cell carcinoma]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Neuroendocrine carcinoma]]
| |
| | Epithelial tumours
| |
| | may have a rhabdoid morphology<ref name=pmid12717248>{{Cite journal | last1 = Perez-Montiel| first1 = MD.| last2 = Frankel| first2 = WL.| last3 = Suster| first3 = S.| title = Neuroendocrine carcinomas of the pancreas with 'Rhabdoid' features.| journal = Am J Surg Pathol| volume = 27| issue = 5| pages = 642-9| month = May| year = 2003| doi = | PMID = 12717248 }}</ref>
| |
| |-
| |
| | [[Medullary thyroid carcinoma]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Thymoma]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Cutaneous myoepithelioma]]
| |
| | Epithelial tumours
| |
| | <ref name=pmid11224605>{{Cite journal | last1 = Kutzner| first1 = H.| last2 = Mentzel| first2 = T.| last3 = Kaddu| first3 = S.| last4 = Soares| first4 = LM.| last5 = Sangueza| first5 = OP.| last6 = Requena| first6 = L.| title = Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.| journal = Am J Surg Pathol| volume = 25| issue = 3| pages = 348-55| month = Mar| year = 2001| doi = | PMID = 11224605 }}</ref>
| |
| |-
| |
| | Cutaneous adnexal tumours ([[spiradenoma]], [[acrospiroma]])
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Hyaline-rich chondroid syringoma]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Hurthle cell tumour]]
| |
| | Epithelial tumours
| |
| |
| |
| |-
| |
| | [[Mesothelioma]]
| |
| | Epithelial tumours
| |
| | "lymphohistiocytoid" variant
| |
| |-
| |
| | [[Seminoma]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |
| |
| |-
| |
| | [[Embryonal carcinoma]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |
| |
| |-
| |
| | [[Yolk sac tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | consider hepatoid variant
| |
| |-
| |
| | [[Choriocarcinoma]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |
| |
| |-
| |
| | [[Epithelioid trophoblastic tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |
| |
| |-
| |
| | [[Granulosa cell tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |
| |
| |-
| |
| | [[Endometrial stromal sarcoma]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | high grade
| |
| |-
| |
| | [[Lipid Cell tumour of ovary]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |
| |
| |-
| |
| | [[Sertoli cell tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | also [[Sertoli-Leydig cell tumour]]
| |
| |-
| |
| | [[Leydig cell tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | also [[Sertoli-Leydig cell tumour]]
| |
| |-
| |
| | [[Epithelioid trophoblastic tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | <ref name=pmid10571512>{{Cite journal | last1 = Hamazaki| first1 = S.| last2 = Nakamoto| first2 = S.| last3 = Okino| first3 = T.| last4 = Tsukayama| first4 = C.| last5 = Mori| first5 = M.| last6 = Taguchi| first6 = K.| last7 = Okada| first7 = S.| title = Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.| journal = Hum Pathol| volume = 30| issue = 11| pages = 1321-7| month = Nov| year = 1999| doi = | PMID = 10571512 }}</ref><ref name=pmid9808132>{{Cite journal | last1 = Shih| first1 = IM.| last2 = Kurman| first2 = RJ.| title = Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.| journal = Am J Surg Pathol| volume = 22| issue = 11| pages = 1393-403| month = Nov| year = 1998| doi = | PMID = 9808132 }}</ref>
| |
| |-
| |
| | [[Placental site trophoblastic tumour]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| |(USCAP04, Gyn spec conf, case 3, vaginal
| |
| |-
| |
| | [[Testicular tumour of the adrenogenital syndrome]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | Inhibin -ve, dark brown-green-black, similar to Leydig tumour
| |
| |-
| |
| | [[Extrauterine lesion of intermediate trophoblast]]
| |
| | Germ- cell / Sex-Cord Stromal
| |
| | very rare
| |
| |-
| |
| | [[Lymphoma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Hodgkin's lymphoma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| | syncytial or lymphocyte-depleted
| |
| |-
| |
| | [[Extramedullary monoblastic leukemia]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Histiocytic sarcoma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| | "True" histiocytic lymphoma
| |
| |-
| |
| | [[Langerhans cell histiocytosis ]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Rosai-Dorfman disease]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Crystal-storing histiocytosis]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Erdheim-Chester disease]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| | foamy histiocytes
| |
| |-
| |
| | [[Rhinoscleroma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| | foamy histiocytes and chronic inflammation
| |
| |-
| |
| | [[Granuloma annulare]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Anaplastic myeloma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Extramedullary myeloid leukemia]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Extramedullary lymphoid leukemia]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Extramedullary megakaryoblastic leukemia]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Erythroleukemia]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| | may be EMA +ve
| |
| |-
| |
| | [[Juvenile xanthogranuloma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Paraganglioma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| | also [[pheochromocytoma]]
| |
| |-
| |
| | [[High grade olfactory neuroblastoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid MPNST]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| | reported to have focal melanocytic differentiation in some cases{{fact}}
| |
| |-
| |
| | [[Glioblastoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid schwannoma / neurofibroma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Benign epithelioid nerve sheath tumour]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Chordoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Meningioma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| | [[chordoid meningioma]]
| |
| |-
| |
| | [[Parachordoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| | <ref name=pmid10478665>{{Cite journal | last1 = Folpe| first1 = AL.| last2 = Agoff| first2 = SN.| last3 = Willis| first3 = J.| last4 = Weiss| first4 = SW.| title = Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.| journal = Am J Surg Pathol| volume = 23| issue = 9| pages = 1059-67| month = Sep| year = 1999| doi = | PMID = 10478665 }}</ref>
| |
| |-
| |
| | [[Ependymoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid perineurioma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Hemangioblastoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| | may be extraneural
| |
| |-
| |
| | [[Rhabdoid tumour]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| | INI1 -ve
| |
| |-
| |
| | [[Mucosal epithelioid nerve sheath tumour]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Neurothekeoma]]
| |
| | Neural - Neuroendocrine - Neuraxis Tumours
| |
| |
| |
| |-
| |
| | [[Pleomorphic rhabdomyosarcoma]]
| |
| | Muscle-related tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid leiomyosarcoma]]
| |
| | Muscle-related tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid glomus tumour]]
| |
| | Muscle-related tumours
| |
| |
| |
| |-
| |
| | [[Granular cell tumour]]
| |
| | Muscle-related tumours
| |
| | neural, non-neural types
| |
| |-
| |
| | [[Rhabdomyoma]]
| |
| | Muscle-related tumours
| |
| |
| |
| |-
| |
| | [[Myopericytoma]]
| |
| | Muscle-related tumours
| |
| | <ref name=pmid16330949>{{Cite journal | last1 = Mentzel| first1 = T.| last2 = Dei Tos| first2 = AP.| last3 = Sapi| first3 = Z.| last4 = Kutzner| first4 = H.| title = Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases.| journal = Am J Surg Pathol| volume = 30| issue = 1| pages = 104-13| month = Jan| year = 2006| doi = | PMID = 16330949 }}</ref>
| |
| |-
| |
| | [[Epithelioid angiosarcoma]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid hemangioendothelioma]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Epith sarcoma-like hemangioendothelioma ]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Composite hemangioendothelioma]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Hemangiopericytoma]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Cutaneous epithelioid angiomatous nodule ]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Bacillary angiomatosis ]]
| |
| | Vascular tumours
| |
| |
| |
| |-
| |
| | [[Malignant pigmented villonodular synovitis]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Multicentric Reticulohistiocytosis]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Follicular dendritic cell sarcoma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Interdigitating reticulum cell sarcoma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |S-100 +ve
| |
| |-
| |
| | [[Diffuse type tenosynovial giant cell tumour]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Malakoplakia]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Kikuchi's disease]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Xanthogranuloma]]
| |
| | Hematolymphoid / Histiocytic tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid sarcoma]]
| |
| | Miscellaneous mesencchymal tumours
| |
| | especially proximal variant
| |
| |-
| |
| | [[Synovial sarcoma]]
| |
| | Miscellaneous mesencchymal tumours
| |
| | poorly differentiated
| |
| |-
| |
| | [[Alveolar soft part sarcoma]]
| |
| | Miscellaneous mesencchymal tumours
| |
| | TFE3 +ve
| |
| |-
| |
| | [[Gastrointestinal stromal tumour]]
| |
| | Miscellaneous mesencchymal tumours
| |
| |
| |
| |-
| |
| | [[Round cell liposarcoma]]
| |
| | Miscellaneous mesencchymal tumours
| |
| |
| |
| |-
| |
| | [[Dedifferentiated liposarcoma]]
| |
| | Miscellaneous mesencchymal tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid variant of pleomorphic liposarcoma]]
| |
| | Miscellaneous mesencchymal tumours
| |
| |
| |
| |-
| |
| | [[Polyphenotypic small cell tumour]]
| |
| | Miscellaneous mesencchymal tumours
| |
| |
| |
| |-
| |
| | [[Ewing Sarcoma / PNET, large cell type]]
| |
| | Miscellaneous mesencchymal tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid fibrous histiocytoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Inflammatory malignant fibrous histiocytoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Sclerosing epithelioid fibrosarcoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Epithlelioid myofibroblastoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Angiomatoid malignant fibrous histiocytoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Inflammatory myxohyaline tumour of distal extremities with virocyte or Reed-Sternberg like cells]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Acral myxoinflammatory fibroblastic sarcoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Angiomyofibroblastoma]]
| |
| | Myofibroblastic - fibroblastic tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid osteosarcoma]]
| |
| | Chondro-osseous tumours
| |
| |
| |
| |-
| |
| | [[Extraskeletal myxoid chondrosarcoma, high grade]]
| |
| | Chondro-osseous tumours
| |
| |
| |
| |-
| |
| | [[Epithelioid multinodular osteoblastoma]]
| |
| | Chondro-osseous tumours
| |
| | may mimic [[osteosarcoma]]<ref name=pmid17667552>{{Cite journal | last1 = Zon Filippi| first1 = R.| last2 = Swee| first2 = RG.| last3 = Krishnan Unni| first3 = K.| title = Epithelioid multinodular osteoblastoma: a clinicopathologic analysis of 26 cases.| journal = Am J Surg Pathol| volume = 31| issue = 8| pages = 1265-8| month = Aug| year = 2007| doi = 10.1097/PAS.0b013e31803402e7| PMID = 17667552 }}</ref>
| |
| |-
| |
| | [[Radiation effect]]
| |
| | Miscellaneous
| |
| |
| |
| |-
| |
| |}
| |
|
| |
|
| ==See also== | | ==See also== |