Difference between revisions of "Fibroblastic/myofibroblastic tumours"

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Fibroblastic/myofibroblastic tumours (view source)

Revision as of 23:26, 6 October 2013

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→‎Solitary fibrous tumour: split-out
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==Solitary fibrous tumour==
==Solitary fibrous tumour==
*Abbreviated ''SFT''.
{{Main|Solitary fibrous tumour}}
===General===
*Grouped with ''hemangiopericytoma'' in the WHO classification - as it is thought to be the same tumour.<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref>
*May be benign ''or'' malignant; more commonly benign.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9]. Accessed on: 25 June 2010.</ref><ref>URL: [http://wjso.com/content/6/1/86 http://wjso.com/content/6/1/86]. Accessed on: 25 June 2010.</ref>
*May be associated with hypoglycemia.
**Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal  | last1 = Roy | first1 = TM. | last2 = Burns | first2 = MV. | last3 = Overly | first3 = DJ. | last4 = Curd | first4 = BT. | title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. | journal = J Ky Med Assoc | volume = 90 | issue = 11 | pages = 557-60 | month = Nov | year = 1992 | doi =  | PMID = 1474302 }}</ref>
 
===Gross===
*Classically arise from the pleura - see ''[[solitary fibrous tumour of the pleura]]''.
 
===Microscopic===
Features - benign:
*Spindle cells in a patternless pattern.
*Hemangiopericytoma-like area ([[staghorn vessels]]).
*Keloid-like collagen bundles - '''key feature'''.
*Usually well-circumscribed.
 
Criteria for malignancy:<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref>
*Necrosis.
*Mitoses >4/10 HPF -- definition suffers from [[HPFitis]].
*Increased cellularity.
*Marked nuclear atypia.
*Infiltrative margin.
 
Images:
*[[WC]]:
**[http://commons.wikimedia.org/wiki/File:Solitary_fibrous_tumour_low_mag.jpg Benign SFT - low mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Solitary_fibrous_tumour_intermed_mag.jpg Benign SFT - intermed. mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Solitary_fibrous_tumour_high_mag.jpg Benign SFT - high mag. (WC)].
*www:
**[http://path.upmc.edu/cases/case272.html SFT of the brain - several images (upmc.edu)].
 
===IHC===
*CD34 ~90% +ve.
*CD99 ~70% +ve.
*BCL2 ~50% +ve.


==Hemangiopericytoma==
==Hemangiopericytoma==
Michael
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