Difference between revisions of "Fibroblastic/myofibroblastic tumours"

Jump to navigation Jump to search

Fibroblastic/myofibroblastic tumours (view source)

Revision as of 02:56, 29 September 2013

2,640 bytes removed ,  02:56, 29 September 2013
→‎Nodular fasciitis: split-out
Line 132: Line 132:


==Nodular fasciitis==
==Nodular fasciitis==
:'''''Not''' to be confused with [[necrotizing fasciitis]]''.
{{Main|Nodular fasciitis}}
===General===
*Benign.
*All age groups.
*Associated with trauma.
 
===Microscopic===
Features:<ref name=Ref_WMSP606>{{Ref WMSP|606}}</ref><ref>{{cite journal |author=de Feraudy S, Fletcher CD |title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases |journal=Am. J. Surg. Pathol. |volume=34 |issue=9 |pages=1377–81 |year=2010 |month=September |pmid=20716998 |doi=10.1097/PAS.0b013e3181ed7374 |url=}}</ref>
*Usu. well-circumscribed.
*Clusters of (non-pleomorphic) spindle cells.
*Inflammation (lymphocytes).
*Microcysts in cellular regions - uncommon - ''discriminatory''.
*Mitoses - common.
*[[Extravasated RBC]]s.
 
The BD feature list:<ref>Dickson, B. 26 April 2011.</ref><ref>URL: [http://anvita.info/wiki/Nodular_Fasciitis http://anvita.info/wiki/Nodular_Fasciitis]. Accessed on: 11 November 2011.</ref>
*Tissue culture-like/CNS-like morphology.
*Thick (keloid-like) collagen bundles - '''key feature'''.
*[[Extravasated RBCs]].
*Inflammation.
*+/-[[Giant cell]]s.
 
Notes:
*No significant nuclear atypia.
*No atypical mitoses.
*May be cellular.
 
DDx:<ref>URL: [http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html]. Accessed on: 11 November 2011.</ref>
*Myxoid [[DFSP]].
*Cellular [[dermatofibroma]].
*[[Desmoid-type fibromatosis]].
 
Images:
*www:
**[http://www.humpath.com/nodular-fasciitis NF (humpath.com)].
*[[WC]]:
**Nephron:
***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-_intermed_mag.jpg NF - case 1 - intermed. mag. (WC)].
***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-_high_mag.jpg NF - case 1 - high mag. (WC)].
***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-2-_intermed_mag.jpg NF - case 2 - intermed. mag. (WC)].
***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-2-_high_mag.jpg NF - case 2 - high mag. (WC)].
**KGH:
***[http://en.wikipedia.org/wiki/File:Nodular_fasciitis_%281%29.JPG NF - low mag. (WC)].
***[http://en.wikipedia.org/wiki/File:Nodular_fasciitis_%282%29.JPG NF - high mag. (WC)].
 
===IHC===
Routine spindle cell panel:
*CD34 -ve.
*Desmin -ve.
*SMA -ve.
*S100 -ve.
*AE1/AE3 -ve.
 
Others:
*H-caldesmon -ve.
*EMA -ve.
*Vimentin +ve.
 
===Molecular===
*Evolving - case reports.
**t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal |author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z |title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region |journal=Cancer Genet. Cytogenet. |volume=141 |issue=2 |pages=160–3 |year=2003 |month=March |pmid=12606136 |doi= |url=}}</ref>


==Desmoid-type fibromatosis==
==Desmoid-type fibromatosis==
Michael
48,475

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/24522"

Navigation menu