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| ==Nodular fasciitis== | | ==Nodular fasciitis== |
| :'''''Not''' to be confused with [[necrotizing fasciitis]]''.
| | {{Main|Nodular fasciitis}} |
| ===General===
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| *Benign.
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| *All age groups.
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| *Associated with trauma.
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| ===Microscopic===
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| Features:<ref name=Ref_WMSP606>{{Ref WMSP|606}}</ref><ref>{{cite journal |author=de Feraudy S, Fletcher CD |title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases |journal=Am. J. Surg. Pathol. |volume=34 |issue=9 |pages=1377–81 |year=2010 |month=September |pmid=20716998 |doi=10.1097/PAS.0b013e3181ed7374 |url=}}</ref>
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| *Usu. well-circumscribed.
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| *Clusters of (non-pleomorphic) spindle cells.
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| *Inflammation (lymphocytes).
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| *Microcysts in cellular regions - uncommon - ''discriminatory''.
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| *Mitoses - common.
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| *[[Extravasated RBC]]s.
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| The BD feature list:<ref>Dickson, B. 26 April 2011.</ref><ref>URL: [http://anvita.info/wiki/Nodular_Fasciitis http://anvita.info/wiki/Nodular_Fasciitis]. Accessed on: 11 November 2011.</ref>
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| *Tissue culture-like/CNS-like morphology.
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| *Thick (keloid-like) collagen bundles - '''key feature'''.
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| *[[Extravasated RBCs]].
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| *Inflammation.
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| *+/-[[Giant cell]]s.
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| Notes:
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| *No significant nuclear atypia.
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| *No atypical mitoses.
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| *May be cellular.
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| DDx:<ref>URL: [http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html]. Accessed on: 11 November 2011.</ref>
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| *Myxoid [[DFSP]].
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| *Cellular [[dermatofibroma]].
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| *[[Desmoid-type fibromatosis]].
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| Images:
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| *www:
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| **[http://www.humpath.com/nodular-fasciitis NF (humpath.com)].
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| *[[WC]]:
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| **Nephron:
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| ***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-_intermed_mag.jpg NF - case 1 - intermed. mag. (WC)].
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| ***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-_high_mag.jpg NF - case 1 - high mag. (WC)].
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| ***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-2-_intermed_mag.jpg NF - case 2 - intermed. mag. (WC)].
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| ***[http://commons.wikimedia.org/wiki/File:Nodular_fasciitis_-2-_high_mag.jpg NF - case 2 - high mag. (WC)].
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| **KGH:
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| ***[http://en.wikipedia.org/wiki/File:Nodular_fasciitis_%281%29.JPG NF - low mag. (WC)].
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| ***[http://en.wikipedia.org/wiki/File:Nodular_fasciitis_%282%29.JPG NF - high mag. (WC)].
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| ===IHC===
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| Routine spindle cell panel:
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| *CD34 -ve.
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| *Desmin -ve.
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| *SMA -ve.
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| *S100 -ve.
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| *AE1/AE3 -ve.
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| Others:
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| *H-caldesmon -ve.
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| *EMA -ve.
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| *Vimentin +ve.
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| ===Molecular===
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| *Evolving - case reports.
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| **t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal |author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z |title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region |journal=Cancer Genet. Cytogenet. |volume=141 |issue=2 |pages=160–3 |year=2003 |month=March |pmid=12606136 |doi= |url=}}</ref>
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| ==Desmoid-type fibromatosis== | | ==Desmoid-type fibromatosis== |