Difference between revisions of "Vermiform appendix"

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Vermiform appendix (view source)

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→‎Goblet cell carcinoid: split-out
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==Goblet cell carcinoid==
==Goblet cell carcinoid==
*[[AKA]] ''crypt cell carcinoma''.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref>
{{Main|Crypt cell carcinoma}}
*[[AKA]] ''[[neuroendocrine tumour]] with goblet cell differentiation''.
===General===
*Rare appendiceal tumour that typically has an aggressive course vis-a-vis other appendiceal carcinoids.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref>
*Mixed (biphasic) tumour with endocrine and exocrine features.
 
===Microscopic===
Features:<ref name=pmid15967038>{{cite journal |author=Pahlavan PS, Kanthan R |title=Goblet cell carcinoid of the appendix |journal=World J Surg Oncol |volume=3 |issue= |pages=36 |year=2005 |month=June |pmid=15967038 |pmc=1182398 |doi=10.1186/1477-7819-3-36 |url=http://wjso.com/content/3/1/36}}</ref>
*Mixed neuroendocrine-nonneuroendocrine tumour;<ref name=pmid17684764>{{cite journal |author=Volante M, Righi L, Asioli S, Bussolati G, Papotti M |title=Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms |journal=Virchows Arch. |volume=451 Suppl 1 |issue= |pages=S61–9 |year=2007 |month=August |pmid=17684764 |doi=10.1007/s00428-007-0447-y |url=}}</ref> features of both ''carcinoid'' and ''adenocarcinoma.<ref name=pmid15967038>PMID 15967038.</ref>
**Archictecture: cells arranged in nests or clusters without a lumen.
**Location: deep to the intestinal crypts (crypts of Lieberkühn); usually do not involve the mucosa.
**Cytoplasm distended with mucin.
**DNA: crescentic nucleus (similar to in signet-ring cells).
***+/-Multinucleation.
***+/-High mitotic rate.
***Usually minimal nuclear atypia.
 
====Images====
<gallery>
Image:Goblet_cell_carcinoid_-2-_very_high_mag.jpg | GCC - very high mag. (WC/Nephron)
Image:Goblet_cell_carcinoid_-_very_low_mag.jpg | GCC - very low mag. (WC/Nephron)
</gallery>
 
===Stains===
*Mucin stains +ve:
**Mucicarmine, perodic acid-Schiff diastase (PAS-D), alician blue.
 
====IHC====
*Classic neuroendocrine markers:
**Synaptophysin +ve.
**Chromogranin +ve.
*S100 +ve.
*NSE +ve.
*Serotonin +ve.
 
Keratins:
*Usually CK20 +ve > CK7 +ve.
 
*CEA +ve (membrane).
 
Notes:
*Nice review of stains in Pahlavan and Kanthan.<ref name=pmid15967038>{{cite journal |author=Pahlavan PS, Kanthan R |title=Goblet cell carcinoid of the appendix |journal=World J Surg Oncol |volume=3 |issue= |pages=36 |year=2005 |month=June |pmid=15967038 |pmc=1182398 |doi=10.1186/1477-7819-3-36 |url=http://wjso.com/content/3/1/36}}</ref>


==Neuroendocrine tumour of the appendix==
==Neuroendocrine tumour of the appendix==
Michael
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