Difference between revisions of "Salivary glands"

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Salivary glands (view source)

Revision as of 13:21, 30 July 2013

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→‎Basal cell adenocarcinoma
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==Basal cell adenocarcinoma==
==Basal cell adenocarcinoma==
*Abbreviated ''BCAC''.
{{Main|Basal cell adenocarcinoma}}
===General===
*Very rare.
*Malignant.
*Good prognosis.
*May arise from a ''[[basal cell adenoma]]''.<ref name=pmid8952553/>
 
===Gross===
*Usually in the parotid gland ~90% of cases.<ref name=pmid8952553>{{Cite journal  | last1 = Muller | first1 = S. | last2 = Barnes | first2 = L. | title = Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature. | journal = Cancer | volume = 78 | issue = 12 | pages = 2471-7 | month = Dec | year = 1996 | doi =  | PMID = 8952553 }}</ref>
 
===Microscopic===
Features:
#Lesion is '''not''' encapsulated - '''key feature'''.
#Basal-like cells:
#*Basophilic cells - '''key feature'''.
#*Usually in nests.
#**May be bilayered tubules ''or'' [[trabeculae]].
#*Large basophilic nucleus.
#*Minimal-to-moderate eosinophilic cytoplasm.
#Stromal cells.
#*Plump spindle cells without significant nuclear atypia.
#**Stromal cell nuclei width ~= diameter [[RBC]].
#*Dense hyaline stroma.
#Tubular component.
#*Within basal component, may be minimal.
 
DDx:
*[[Adenoid cystic carcinoma]].
*[[Basal cell adenoma]] - encapsulated.
*Basaloid [[squamous cell carcinoma]].
 
====Images====
<gallery>
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_intermed_mag.jpg | BCAC - intermed. mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron)
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=5&Case=115 Basal cell adenocarcinoma - intermed. mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=6&Case=115 Basal cell adenocarcinoma - high mag. (webpathology.com)].
 
===IHC===
Features:<ref name=pmid17922602>{{Cite journal  | last1 = Farrell | first1 = T. | last2 = Chang | first2 = YL. | title = Basal cell adenocarcinoma of minor salivary glands. | journal = Arch Pathol Lab Med | volume = 131 | issue = 10 | pages = 1602-4 | month = Oct | year = 2007 | doi = 10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2 | PMID = 17922602 }}</ref>
*CK7 +ve (strong).
*S100 +ve/-ve.


==Sebaceous carcinoma==
==Sebaceous carcinoma==
Michael
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