Difference between revisions of "Salivary glands"

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Salivary glands (view source)

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→‎Epithelial-myoepithelial carcinoma: split out
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==Epithelial-myoepithelial carcinoma==
==Epithelial-myoepithelial carcinoma==
*Abbreviated ''EMCa''.
{{Main|Epithelial-myoepithelial carcinoma}}
 
===General===
*Rare ~1% of salivary gland tumours.<ref  name=pmid9568184>{{Cite journal  | last1 = Tralongo | first1 = V. | last2 = Daniele | first2 = E. | title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. | journal = Anticancer Res | volume = 18 | issue = 1B | pages = 603-8 | month =  | year =  | doi =  | PMID = 9568184 }}</ref>
*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal  | last1 = Seethala | first1 = RR. | last2 = Barnes | first2 = EL. | last3 = Hunt | first3 = JL. | title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. | journal = Am J Surg Pathol | volume = 31 | issue = 1 | pages = 44-57 | month = Jan | year = 2007 | doi = 10.1097/01.pas.0000213314.74423.d8 | PMID = 17197918 }}</ref>
*Usu. older people - 50s or 60s.
*Usu. parotid gland ~ 60% of cases.<ref name=pmid17197918/>
*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>
 
Notes:
*Most common malignant component in ''[[carcinoma ex pleomorphic adenoma]]''.
*May be the same tumour as ''[[adenomyoepithelioma]] of the breast''.<ref name=pmid9769134>{{Cite journal  | last1 = Seifert | first1 = G. | title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? | journal = Virchows Arch | volume = 433 | issue = 3 | pages = 285-8 | month = Sep | year = 1998 | doi =  | PMID = 9769134 }}</ref>
 
===Microscopic===
Features:
*Biphasic tumour:<ref name=pmid17197918/>
*#Epithelial layer.
*#Myoepithelial layer - '''key feature'''.
*Architecture: variable (solid, cystic, tubular, papillary).
*+/-Spindle cells.
*Basement membrane-like material; may mimic adenoid cystic carcinoma.
 
Notes:
*Usually few mitoses.
 
DDx:
*[[Adenoid cystic carcinoma]] (tubular variant).
*[[Pleomorphic adenoma]], tubular variant.
**Has focal epithelial-myoepithelial carcinoma-like areas.
 
====Images====
<gallery>
Image:Epithelial-myoepithelial_carcinoma_-_intermed_mag.jpg | EMCa - intermed. mag. (WC/Nephron)
Image:Epithelial-myoepithelial_carcinoma_-_high_mag.jpg | EMCa - high mag. (WC/Nephron)
Image:Epithelial-myoepithelial carcinoma - very high mag.jpg | EMCa - very high mag. (WC/Nephron)
</gallery>
www:
*[http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/images-features/emc-rev-cyto1-18.jpg EMCa  (pathologyimagesinc.com)].<ref>{{cite web |url=http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html |title=Cytopathologic Features of
Epithelial-myoepithelial Carcinoma |last1= |first1= |last2= |first2= |date= |work= |publisher= |accessdate=January 18, 2011}}</ref>
*[http://www.headandneckoncology.org/content/2/1/4 EMCa (headandneckoncology.org)].
 
===IHC===
*CAM5.2 +ve -- epithelial component.
*p63 +ve -- myoepithelial component.


==Basal cell adenocarcinoma==
==Basal cell adenocarcinoma==
Michael
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