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Difference between revisions of "Gonadoblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Gonadoblastoma_-_b_-_high_mag.jpg | |||
| Width = | |||
| Caption = Gondaloblastoma. [[H&E stain]]. | |||
| Micro = immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a [[dysgerminoma]], | |||
+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. | |||
| Subtypes = | |||
| LMDDx = [[dysgerminoma]] | |||
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| Gross = | |||
| Grossing = | |||
| Site = [[ovary]] | |||
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}} | |||
'''Gonadoblastoma''' is a rare [[germ cell tumour]] with sex cord elements. | |||
==General== | |||
*Associated with abnormal sexual development. | |||
*Often coexist with a [[dysgerminoma]]. | |||
*A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements. | |||
==Gross== | |||
*+/-Cystic. | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref> | |||
*Immature germ cells resembling Sertoli cells or granulosa cells. | |||
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture. | |||
**Granulosa cells = form follicle-like structures. | |||
***May form nests. | |||
*Primitive germ cells resemble those of a [[dysgerminoma]]. | |||
**Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm. | |||
*+/-Calcification (very common). | |||
*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Gonadoblastoma_-_intermed_mag.jpg | Gonadoblastoma - intermed. mag. (WC/Nephron) | |||
Image:Gonadoblastoma_-_b_-_high_mag.jpg | Gonadoblastoma - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=40&Case=532 Gonadoblastoma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=532&n=42 Gonadoblastoma - high mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=532&n=44 Gonadoblastoma - high mag. (webpathology.com)]. | |||
*[http://www.flickr.com/photos/ckrishnan/3972431774/in/photostream/ Gonadoblastoma - low mag. (flickr.com)]. | |||
*[http://www.flickr.com/photos/ckrishnan/3972432404/in/photostream/ Gonadoblastoma - intermed. mag. (flickr.com)]. | |||
*[http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ Gonadoblastoma - high mag. (flickr.com)]. | |||
*[http://path.upmc.edu/cases/case356.html Gonadoblastoma - several cases (upmc.edu)]. | |||
==See also== | |||
*[[Germ cell tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||