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Difference between revisions of "Malignant melanoma"
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| Micro = melanocytic differentiation (e.g. pigment), abnormal architecture, lack of maturation, +/-nuclear atypia - esp. nucleoli, +/-upward scatter of melanocytes, +/-asymmetry of pigmentation | | Micro = melanocytic differentiation (e.g. pigment), abnormal architecture, lack of maturation, +/-nuclear atypia - esp. nucleoli, +/-upward scatter of melanocytes, +/-asymmetry of pigmentation | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[dysplastic nevus]], [[Spitz nevus]], [[common nevus]] (nevoid melanoma), [[atypical fibroxanthoma]], (spindle cell) [[squamous cell carcinoma]], [[leiomyosarcoma]], | | LMDDx = [[dysplastic nevus]], [[Spitz nevus]], [[common nevus]] (nevoid melanoma), [[atypical fibroxanthoma]], (spindle cell) [[squamous cell carcinoma]], [[leiomyosarcoma]], [[serous carcinoma]], [[clear cell sarcoma]], others | ||
| Stains = melanin | | Stains = melanin | ||
| IHC = S-100, Melan A, HMB-45, | | IHC = S-100, Melan A, HMB-45, MITF, tyrosinase | ||
| EM = melanosomes | | EM = melanosomes | ||
| Molecular = | | Molecular = | ||