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Difference between revisions of "Pediatric pathology"
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→Juvenile xanthogranuloma
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*Must prove they are non-Langerhans cell histiocytes, esp. if no Touton giant cells. | *Must prove they are non-Langerhans cell histiocytes, esp. if no Touton giant cells. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Juvenile_xanthogranuloma_-_intermed_mag.jpg | Juvenile xanthogranuloma - intermed. mag. (WC) | |||
Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg | Touton giant cells in a juvenile xanthogranuloma - very high mag. (WC) | |||
</gallery> | |||
===IHC=== | ===IHC=== | ||
Features:<ref name=emed_jxg/> | Features:<ref name=emed_jxg/> | ||
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*Histiocyte markers: CD68, CD163 -- both should be positive. | *Histiocyte markers: CD68, CD163 -- both should be positive. | ||
*Vimentin +ve. | *Vimentin +ve. | ||
Other markers:<ref name=pmid11285404>{{Cite journal | last1 = Kraus | first1 = MD. | last2 = Haley | first2 = JC. | last3 = Ruiz | first3 = R. | last4 = Essary | first4 = L. | last5 = Moran | first5 = CA. | last6 = Fletcher | first6 = CD. | title = Juvenile xanthogranuloma: an immunophenotypic study with a reappraisal of histogenesis. | journal = Am J Dermatopathol | volume = 23 | issue = 2 | pages = 104-11 | month = Apr | year = 2001 | doi = | PMID = 11285404 }}</ref> | |||
*CD4 +ve (21 of 27 cases). | |||
*CD45 +ve (25 of 27 cases). | |||
*Factor XIIIa +ve (25 of 27 cases). | |||
Negatives:<ref name=pmid9790615>{{cite journal |author=Thomas DB, Sidler AK, Huston BM |title=Radiological case of the month. Juvenile xanthogranuloma |journal=Arch Pediatr Adolesc Med |volume=152 |issue=10 |pages=1029–30 |year=1998 |month=October |pmid=9790615 |doi= |url=http://archpedi.ama-assn.org/cgi/content/full/152/10/1029}}</ref> | Negatives:<ref name=pmid9790615>{{cite journal |author=Thomas DB, Sidler AK, Huston BM |title=Radiological case of the month. Juvenile xanthogranuloma |journal=Arch Pediatr Adolesc Med |volume=152 |issue=10 |pages=1029–30 |year=1998 |month=October |pmid=9790615 |doi= |url=http://archpedi.ama-assn.org/cgi/content/full/152/10/1029}}</ref> | ||