48,830
edits
Difference between revisions of "Vermiform appendix"
Jump to navigation
Jump to search
→Mucinous tumours of the appendix: +comparison table
(→Mucinous tumours of the appendix: +comparison table) |
|||
| Line 216: | Line 216: | ||
*[[Onlinepathology]] prefers the classification of Misdraji,<ref name=pmid12883241>{{cite journal |author=Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH |title=Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases |journal=Am. J. Surg. Pathol. |volume=27 |issue=8 |pages=1089–103 |year=2003 |month=August |pmid=12883241 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=27&issue=8&spage=1089}}</ref> as it is the least complicated | *[[Onlinepathology]] prefers the classification of Misdraji,<ref name=pmid12883241>{{cite journal |author=Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH |title=Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases |journal=Am. J. Surg. Pathol. |volume=27 |issue=8 |pages=1089–103 |year=2003 |month=August |pmid=12883241 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=27&issue=8&spage=1089}}</ref> as it is the least complicated | ||
====Misdraji | ====Misdraji classification==== | ||
*Benign - ''low grade mucinous tumour''. | *Benign - ''low grade mucinous tumour''. | ||
*Borderline - ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour''. | *Borderline - ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour''. | ||
*Malignant - ''mucinous adenocarcinoma''. | *Malignant - ''mucinous adenocarcinoma''. | ||
Five year survival (in a series of 107 cases):<ref name=pmid12883241/> | Five year survival (in a series of 107 cases) as per Misdraji classification:<ref name=pmid12883241/> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
!Tumour | !Tumour | ||
| Line 239: | Line 239: | ||
*LAMN extra-appendiceal = low-grade appendiceal mucinous neoplasm with extra-appendiceal spread. | *LAMN extra-appendiceal = low-grade appendiceal mucinous neoplasm with extra-appendiceal spread. | ||
*MACA = mucinous adenocarcinoma of the appendix. | *MACA = mucinous adenocarcinoma of the appendix. | ||
====WHO classification==== | |||
WHO classification: | |||
*Adenoma with low-grade dysplasia. | |||
*Adenoma with high-grade dysplasia. | |||
*Low-grade invasive mucinous adenocarcinoma | |||
**Confined to the appendiceal wall. | |||
**Outside of the appendix. | |||
*High-grade invasive mucinous adenocarcinoma. | |||
====Comparison between Misdraji and WHO classification==== | |||
Adapted from ''Panarelli and Yantiss'':<ref name=pmid21970481>{{Cite journal | last1 = Panarelli | first1 = NC. | last2 = Yantiss | first2 = RK. | title = Mucinous neoplasms of the appendix and peritoneum. | journal = Arch Pathol Lab Med | volume = 135 | issue = 10 | pages = 1261-8 | month = Oct | year = 2011 | doi = 10.5858/arpa.2011-0034-RA | PMID = 21970481 }}</ref> | |||
{| class="wikitable sortable" | |||
! Stage | |||
! Cytologic dysplasia | |||
! Misdraji | |||
! WHO | |||
|- | |||
| Confined to the mucosa | |||
| low-grade | |||
| low-grade appendiceal mucinous neoplasm (LAMN) | |||
| mucinous adenoma, negative for high-grade dysplasia | |||
|- | |||
| Confined to the mucosa | |||
| high-grade | |||
| non-invasive mucinous cystadenocarcinoma of the appendix | |||
| mucinous adenoma with high-grade dysplasia | |||
|- | |||
| At least into the submucosa, confined to the appendix | |||
| low-grade | |||
| low-grade appendiceal mucinous neoplasm (LAMN) | |||
| invasive mucinous adenocarcinoma, low-grade | |||
|- | |||
| At least into the submucosa, confined to the appendix | |||
| high-grade | |||
| mucinous adenocarcinoma of the appendix (MACA) | |||
| invasive mucinous adenocarcinoma, high-grade | |||
|- | |||
| Extra-appendiceal spread | |||
| low-grade | |||
| low-grade appendiceal mucinous neoplasm (LAMN) | |||
| invasive mucinous adenocarcinoma, low-grade | |||
|- | |||
| Extra-appendiceal spread | |||
| high-grade | |||
| mucinous adenocarcinoma of the appendix (MACA) | |||
| invasive mucinous adenocarcinoma, high-grade | |||
|} | |||
===Microscopic=== | ===Microscopic=== | ||