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Difference between revisions of "Liver pathology"
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*Cytoplasm cleared with "whisps" or cobbwebs. | *Cytoplasm cleared with "whisps" or cobbwebs. | ||
*Large relative to normal hepatocyte. | *Large relative to normal hepatocyte. | ||
**2-3X normal size.<ref> | **2-3X normal size.<ref>Guindi, M. 16 September 2009.</ref> | ||
Notes: | Notes: | ||
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Quantity of fat is usually given as a percentage and graded ''mild'', ''moderate'', or ''marked''. | Quantity of fat is usually given as a percentage and graded ''mild'', ''moderate'', or ''marked''. | ||
*Mild <33%, moderate >33% & <66%, marked >66%.<ref> | *Mild <33%, moderate >33% & <66%, marked >66%.<ref>Guindi, M. September 17, 2009.</ref> | ||
Notes: | Notes: | ||
*It is considered technically incorrect to say the liver, in steatosis/steatohepatitis, contains ''adipocytes''; they are ''lipid-laden hepatocytes'',<ref> | *It is considered technically incorrect to say the liver, in steatosis/steatohepatitis, contains ''adipocytes''; they are ''lipid-laden hepatocytes'',<ref>Guindi, M. September 2009.</ref> despite that: | ||
**Histologically, these cells look like adipocytes. | **Histologically, these cells look like adipocytes. | ||
**Lipid-laden hepatocytes have gene activations suggestive of adipogenic-like transformation.<ref>URL: [http://www.jci.org/articles/view/20513/version/1 http://www.jci.org/articles/view/20513/version/1]. Accessed on: 23 September 2009.</ref> | **Lipid-laden hepatocytes have gene activations suggestive of adipogenic-like transformation.<ref>URL: [http://www.jci.org/articles/view/20513/version/1 http://www.jci.org/articles/view/20513/version/1]. Accessed on: 23 September 2009.</ref> | ||
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=====Brown/yellow cytoplasmic inclusions===== | =====Brown/yellow cytoplasmic inclusions===== | ||
Comparison of brown/yellow cytoplasmic inclusions:<ref> | Comparison of brown/yellow cytoplasmic inclusions:<ref>Guindi, M. September 2009.</ref> | ||
{| class="wikitable sortable" border="1" | {| class="wikitable sortable" border="1" | ||
! Finding | ! Finding | ||