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Difference between revisions of "Lymph nodes"
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*White lesions, especially irregular = suggestive of carcinoma. | *White lesions, especially irregular = suggestive of carcinoma. | ||
*White, glistening, with lobulated surface - "fish flesh" = suggestive of lymphoma. | *White, glistening, with lobulated surface - "fish flesh" = suggestive of lymphoma. | ||
**Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref> | **Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref>Bailey, D. 5 August 2010.</ref> | ||
=Microscopic= | =Microscopic= | ||
== | ==Lymph node architecture== | ||
Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4|206-8}}</ref> | Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4|206-8}}</ref> | ||
*Capsule. | *Capsule. | ||
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*[[Trabeculae]] - segment the LN radially, i.e. are spoke-like structures. | *[[Trabeculae]] - segment the LN radially, i.e. are spoke-like structures. | ||
== | ==Lymph node follicles== | ||
Types of follicles:<ref name=Ref_WFH4_208>{{Ref WFH4|208}}</ref> | Types of follicles:<ref name=Ref_WFH4_208>{{Ref WFH4|208}}</ref> | ||
#Primary follicle - no germinal center (pale area). | #Primary follicle - no germinal center (pale area). | ||
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*Usually asymmetrical; thicker, i.e. more mantle cells, at capsular aspect.<ref>DG. 17 August 2010.</ref> | *Usually asymmetrical; thicker, i.e. more mantle cells, at capsular aspect.<ref>DG. 17 August 2010.</ref> | ||
==B | ==Cell types== | ||
Follicular dendritic cells:<ref name=pmid9258622>{{cite journal |author=Wright CA, Nayler SJ, Leiman G |title=Cytopathology of follicular dendritic cell tumors |journal=Diagn. Cytopathol. |volume=17 |issue=2 |pages=138–42 |year=1997 |month=August |pmid=9258622 |doi= |url=http://www3.interscience.wiley.com/journal/57062/abstract?CRETRY=1&SRETRY=0}}</ref> | |||
*Classically found in pairs. | |||
*Large nucleus with: | |||
**Basketweave chromatin pattern. | |||
**Small central nucleolus. | |||
Lymphocytes: | |||
*See ''B lymphocytes'' section. | |||
===B lymphocytes=== | |||
*B cells are best understood in the context of their maturation. | |||
B cell cycle/maturation:<ref name=Ref_WFH4_210>{{Ref WFH4|210}}</ref> | B cell cycle/maturation:<ref name=Ref_WFH4_210>{{Ref WFH4|210}}</ref> | ||
#Centroblast (CB): | #Centroblast (CB): | ||
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*[http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm Lymphoid organs (healthsystem.virginia.edu)]. | *[http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm Lymphoid organs (healthsystem.virginia.edu)]. | ||
= | ===Cell types - table=== | ||
==Cell types - table== | |||
{| class="wikitable" | {| class="wikitable" | ||
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*[[Basics]]. | *[[Basics]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
=External links= | |||
*[http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Lymph node architecture (umdnj.edu)]. | *[http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Lymph node architecture (umdnj.edu)]. | ||
[[Category:Haematopathology]] | [[Category:Haematopathology]] | ||