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Difference between revisions of "Common variable immunodeficiency"
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Common variable immunodeficiency (view source)
Revision as of 04:41, 7 March 2013
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*Recurrent sinus and pulmonary infections. | *Recurrent sinus and pulmonary infections. | ||
*[[Inflammatory bowel disease]]-like disease. | *[[Inflammatory bowel disease]]-like disease. | ||
==Gross== | |||
Duodenum: | |||
*Nodular mucosa - due to lymphoid hyperplasia. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features - general: | ||
*[[Plasma cells]] absent (or reduced) - '''key feature'''.<ref name=pmid20629103>{{cite journal |author=Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L |title=Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease |journal=Inflamm Bowel Dis |volume= |issue= |pages= |year=2010 |month=July |pmid=20629103 |doi=10.1002/ibd.21376 |url=}}</ref> | *[[Plasma cells]] absent (or reduced) - '''key feature'''.<ref name=pmid20629103>{{cite journal |author=Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L |title=Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease |journal=Inflamm Bowel Dis |volume= |issue= |pages= |year=2010 |month=July |pmid=20629103 |doi=10.1002/ibd.21376 |url=}}</ref> | ||
*+/-Lymphoid aggregates. | |||
===Esophagus=== | |||
Features - esophagus:<ref name=pmid18043034>{{Cite journal | last1 = Daniels | first1 = JA. | last2 = Lederman | first2 = HM. | last3 = Maitra | first3 = A. | last4 = Montgomery | first4 = EA. | title = Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1800-12 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e3180cab60c | PMID = 18043034 }}</ref> | |||
*Intraepithelial PMNs & candida. | |||
*+/-Abundant intraepithelial lymphocytes. | |||
===Stomach=== | |||
Features - stomach:<ref name=pmid18043034/> | |||
*Lack of [[plasma cell]]s ~ 2/3 of individuals - '''key feature''' | |||
*Lymphoid aggregates - common. | |||
*+/-[[Lymphocytic gastritis]]. | |||
*+/-Intraepithelial neutrophils. | |||
*+/-Infections ([[CMV]], [[H. pylori]], [[cryptosporidium]]). | |||
===Small bowel=== | |||
Features - small bowel:<ref name=pmid18043034/> | |||
*Villous blunting > 80% of individuals. | |||
*Decreased plasma cells ~ 2/3 of individuals - '''key feature'''. | |||
*Lymphoid aggregates ~ 1/2 of individuals. | |||
*+/-Neutrophils + infections (CMV, cryptosporidium). | |||
===Large bowel=== | |||
Features:<ref name=pmid18043034/> | |||
*Decreased plasma cells - '''key feature'''. | |||
*Lymphoid aggregates. | |||
*+/-Apparent apoptosis. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Haematopathology]] | [[Category:Haematopathology]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||