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Difference between revisions of "Medical kidney diseases"
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Medical kidney diseases (view source)
Revision as of 13:51, 23 September 2010
, 13:51, 23 September 2010→Microscopic
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid19825147>{{cite journal |author=Zelmanovitz T, Gerchman F, Balthazar AP, Thomazelli FC, Matos JD, Canani LH |title=Diabetic nephropathy |journal=Diabetol Metab Syndr |volume=1 |issue=1 |pages=10 |year=2009 |pmid=19825147 |pmc=2761852 |doi=10.1186/1758-5996-1-10 |url=}}</ref> | ||
*Thick glomerular basement membrane (GBM). | *Thick glomerular basement membrane (GBM). | ||
*Thickening of tunica media in both the afferent and efferent arterioles.<ref name=pmid12032631>{{cite journal |author=Østerby R, Hartmann A, Bangstad HJ |title=Structural changes in renal arterioles in Type I diabetic patients |journal=Diabetologia |volume=45 |issue=4 |pages=542–9 |year=2002 |month=April |pmid=12032631 |doi=10.1007/s00125-002-0780-2 |url=}}</ref> | |||
*Mesangial matrix expansion - leads to nodule formation ''Kimmelstiel-Wilson nodules'' (''nodular glomerulosclerosis''). | *Mesangial matrix expansion - leads to nodule formation ''Kimmelstiel-Wilson nodules'' (''nodular glomerulosclerosis''). | ||
Other - with weak evidence: | Other - with weak evidence: | ||
*Extra efferent vessels.<ref name=pmid17490718>{{cite journal |author=Stout LC, Whorton EB |title=Pathogenesis of extra efferent vessel development in diabetic glomeruli |journal=Hum. Pathol. |volume=38 |issue=8 |pages=1167–77 |year=2007 |month=August |pmid=17490718 |doi=10.1016/j.humpath.2007.01.019 |url=}}</ref> | *Extra efferent vessels.<ref name=pmid17490718>{{cite journal |author=Stout LC, Whorton EB |title=Pathogenesis of extra efferent vessel development in diabetic glomeruli |journal=Hum. Pathol. |volume=38 |issue=8 |pages=1167–77 |year=2007 |month=August |pmid=17490718 |doi=10.1016/j.humpath.2007.01.019 |url=}}</ref> | ||
Memory device: | |||
*GBM = thick '''G'''BM, '''B'''oth afferent & efferent artiole thickened, '''M'''esangial matrix expansion. | |||
Image: [http://en.wikipedia.org/wiki/File:Nodular_glomerulosclerosis.jpeg Nodular glomerulosclerosis (WP)]. | Image: [http://en.wikipedia.org/wiki/File:Nodular_glomerulosclerosis.jpeg Nodular glomerulosclerosis (WP)]. | ||