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There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia, | There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia, | ||
nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic | nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic | ||
ratio. Mitotic activity is abundant. Several atypical mitoses are identified. | ratio. Mitotic activity is abundant. Several atypical mitoses are identified. | ||
The dysplastic squamous epithelium shows minimal maturation toward the surface. | The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A | ||
sizable portion of the lesion show some maturation to the surface (AIN 2). | |||
Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal interface is well-demarcated | Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal | ||
interface is well-demarcated. Focal ulceration is present. | |||
The margin of the biopsy has severely dysplastic epithelium (AIN 3). | |||
=Anal cancer= | =Anal cancer= |
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