Difference between revisions of "Urothelium"

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===Flat urothelial lesions===
===Flat urothelial lesions===
Comparison urothelial changes - flat epithelium - benign/premalignant/cancerous:<ref>{{Ref GUP|155-163}}</ref>
Comparison urothelial changes - flat epithelium - benign/premalignant/cancerous:<ref>{{Ref GUP|155-163}}</ref>
{| class="wikitable"
{| class="wikitable sortable"
| '''Features'''
! Diagnosis
! Nuclear enlargement<br>(X stromal lymphocyte)
! Nucleoli
! size var., shape
! Polarity
! Mitoses
! Thickness
! Inflammation
! Other
|-
| '''Normal'''
| '''Normal'''
| '''Reactive atypia'''
| none (2x)
| small
| none, round
| matures to surface
| none/minimal
| 4-5 cells
| none
| -
|-
|'''Reactive atypia'''
| moderate, prominent (3x)
| prominent
| none, round
| as normal
| some, none atypical
| as normal
| '''severe, acute or chronic'''
| -
|-
| '''Flat urothelial hyperplasia'''
| '''Flat urothelial hyperplasia'''
| none (2x)
| small
| none, round
| as normal
| as normal
| '''increased'''
| usu. none
| -
|-
| '''Urothelial dysplasia'''
| '''Urothelial dysplasia'''
| moderate (3x)
| small, some multiple
| mod. variation, some irregularity
| '''lost'''
| rare, none atypical
| as normal
| usu. none
| -
|-
| '''UCC in situ'''
| '''UCC in situ'''
| '''signif. (4-5x)'''
| +/-large
| marked, irregular
| lost
| common, atypical
| thin, thick or norm.
| +/-
| -
|-
| '''Invasive UCC'''
| '''Invasive UCC'''
|-
|Nuclear enlargement<br>(X stromal lymphocyte)
| none (2x)
| moderate, prominent (3x)
| none (2x)
| moderate (3x)
| '''signif. (4-5x)'''
| signif. (4-5X)
| signif. (4-5X)
|-
| +/-large
|Nucleoli
| small
| prominent
| small
| small, some multiple
| +/-large
| +/-large
|-
|size var., shape
| none, round
| none, round
| none, round
| mod. variation, some irregularity
| marked, irregular
| marked, irregular
| marked, irregular
|-
|Polarity
| matures to surface
| as normal
| as normal
| '''lost'''
| lost
| lost
| lost
|-
|Mitoses
| none/minimal
| some, none atypical
| as normal
| rare, none atypical
| common, atypical
| common, atypical
| common, atypical
|-
|Thickness
| 4-5 cells
| as normal
| '''increased'''
| as normal
| thin, thick or norm.
| thin, thick or norm.
| thin, thick or norm.
|-
|Inflammation
| none
| '''severe, acute or chronic'''
| usu. none
| usu. none
| +/-
| +/-
| +/-
|-
|Other
| -
| -
| -
| -
| -
| '''stromal invasion'''
| '''stromal invasion'''
|-
|-
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