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(→Flat urothelial lesions: more) |
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===Flat urothelial lesions=== | ===Flat urothelial lesions=== | ||
Comparison urothelial changes - flat epithelium - benign/premalignant/cancerous:<ref>{{Ref GUP|155-163}}</ref> | Comparison urothelial changes - flat epithelium - benign/premalignant/cancerous:<ref>{{Ref GUP|155-163}}</ref> | ||
{| class="wikitable" | {| class="wikitable sortable" | ||
| | ! Diagnosis | ||
! Nuclear enlargement<br>(X stromal lymphocyte) | |||
! Nucleoli | |||
! size var., shape | |||
! Polarity | |||
! Mitoses | |||
! Thickness | |||
! Inflammation | |||
! Other | |||
|- | |||
| '''Normal''' | | '''Normal''' | ||
| '''Reactive atypia''' | | none (2x) | ||
| small | |||
| none, round | |||
| matures to surface | |||
| none/minimal | |||
| 4-5 cells | |||
| none | |||
| - | |||
|- | |||
|'''Reactive atypia''' | |||
| moderate, prominent (3x) | |||
| prominent | |||
| none, round | |||
| as normal | |||
| some, none atypical | |||
| as normal | |||
| '''severe, acute or chronic''' | |||
| - | |||
|- | |||
| '''Flat urothelial hyperplasia''' | | '''Flat urothelial hyperplasia''' | ||
| none (2x) | |||
| small | |||
| none, round | |||
| as normal | |||
| as normal | |||
| '''increased''' | |||
| usu. none | |||
| - | |||
|- | |||
| '''Urothelial dysplasia''' | | '''Urothelial dysplasia''' | ||
| moderate (3x) | |||
| small, some multiple | |||
| mod. variation, some irregularity | |||
| '''lost''' | |||
| rare, none atypical | |||
| as normal | |||
| usu. none | |||
| - | |||
|- | |||
| '''UCC in situ''' | | '''UCC in situ''' | ||
| '''signif. (4-5x)''' | |||
| +/-large | |||
| marked, irregular | |||
| lost | |||
| common, atypical | |||
| thin, thick or norm. | |||
| +/- | |||
| - | |||
|- | |||
| '''Invasive UCC''' | | '''Invasive UCC''' | ||
| signif. (4-5X) | | signif. (4-5X) | ||
| +/-large | |||
| +/-large | |||
| marked, irregular | | marked, irregular | ||
| lost | | lost | ||
| common, atypical | | common, atypical | ||
| thin, thick or norm. | | thin, thick or norm. | ||
| +/- | | +/- | ||
| '''stromal invasion''' | | '''stromal invasion''' | ||
|- | |- |
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