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Comparison urothelial changes - flat epithelium - benign/premalignant/cancerous:<ref>{{Ref GUP|155-163}}</ref> | Comparison urothelial changes - flat epithelium - benign/premalignant/cancerous:<ref>{{Ref GUP|155-163}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
| | | '''Features''' | ||
| '''Normal''' | |||
| '''Reactive atypia''' | |||
| '''Flat urothelial hyperplasia''' | |||
| '''Urothelial dysplasia''' | |||
| '''UCC in situ''' | |||
| '''Invasive UCC''' | |||
|- | |- | ||
|Nuclear enlargement<br>(X stromal lymphocyte) | |Nuclear enlargement<br>(X stromal lymphocyte) | ||
| none (2x) | |||
| moderate, prominent (3x) | |||
| none (2x) | |||
| moderate (3x) | |||
| '''signif. (4-5x)''' | |||
| signif. (4-5X) | |||
|- | |- | ||
|Nucleoli | |Nucleoli | ||
| small | |||
| prominent | |||
| small | |||
| small, some multiple | |||
| +/-large | |||
| +/-large | |||
|- | |- | ||
|size var., shape | |size var., shape | ||
| none, round | |||
| none, round | |||
| none, round | |||
| mod. variation, some irregularity | |||
| marked, irregular | |||
| marked, irregular | |||
|- | |- | ||
|Polarity | |Polarity | ||
| matures to surface | |||
| as normal | |||
| as normal | |||
| '''lost''' | |||
| lost | |||
| lost | |||
|- | |- | ||
|Mitoses | |Mitoses | ||
| none/minimal | |||
| some, none atypical | |||
| as normal | |||
| rare, none atypical | |||
| common, atypical | |||
| common, atypical | |||
|- | |- | ||
|Thickness | |Thickness | ||
| 4-5 cells | |||
| as normal | |||
| '''increased''' | |||
| as normal | |||
| thin, thick or norm. | |||
| thin, thick or norm. | |||
|- | |- | ||
|Inflammation | |Inflammation | ||
| none | |||
| '''severe, acute or chronic''' | |||
| usu. none | |||
| usu. none | |||
| +/- | |||
| +/- | |||
|- | |- | ||
|Other | |Other | ||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| '''stromal invasion''' | |||
|- | |- | ||
|} | |} |
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